Evaluation of Theophylline-Stimulated Changes in Carnitine Palmitoyltransferase Activity in Skeletal Muscle and Liver of Rats

The effect of theophylline treatments on the activity of carnitine palmitoyltransferase (CPT) in skeletal muscle and the liver of rats was investigated. Theophylline was administered at 100 mg/kg bw/day and effects were monitored after a treatment period that lasted between a week and five weeks. Re...

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Bibliographic Details
Published in:Journal of enzyme inhibition 2001, Vol.16 (2), p.177-183
Main Author: Alhomida, A. S.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Carnitine O-Palmitoyltransferase - metabolism
Carnitine palmitoyltransferase
Kinetics
Lipolysis
Liver
Liver - enzymology
Male
Muscle
Muscle, Skeletal - enzymology
Placebos
Rat
Rats
Rats, Wistar
Theophylline
Theophylline - administration & dosage
Theophylline - pharmacology
Time Factors
β-oxidation
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Summary:The effect of theophylline treatments on the activity of carnitine palmitoyltransferase (CPT) in skeletal muscle and the liver of rats was investigated. Theophylline was administered at 100 mg/kg bw/day and effects were monitored after a treatment period that lasted between a week and five weeks. Results showed that a significant increase in the activity of CPT was observed in skeletal muscle of theophyl-line-treated groups as compared to either control or placebo groups. However, there was no significant change in the activity of CPT in the hepatic tissues of theophylline-treated groups. The observed discrepancies in activity of CPT might be due to the presence of two isoenzymes, the muscle type (M-CPT) and liver type (L-CPT); it is possible that theophylline affects only M-CPT activity.
ISSN:1475-6366
8755-5093
1475-6374
DOI:10.1080/14756360109162367