Pre-polarized saline: an in vivo feasibility study of a potential contrast agent

The potential for using pre‐polarized liquids as contrast agents in vivo is investigated and the feasibility of the method demonstrated. In this study we show the enhancement obtained following intravenous delivery of pre‐polarized saline into the antecubital vein of a volunteer. This form of contra...

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Bibliographic Details
Published in:NMR in biomedicine 1999-10, Vol.12 (6), p.381-386
Main Authors: Young, Ian R., deSouza, Nandita M., Hall, Alasdair S., Williams, Andreanna D., Hajnal, Joseph V., Coutts, Glyn A.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
contrast agents
Contrast Media - chemistry
Contrast media. Radiopharmaceuticals
Feasibility Studies
Humans
in vivo demonstration
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - instrumentation
Magnetic Resonance Imaging - methods
Male
Medical sciences
Miscellaneous. Technology
Phantoms, Imaging
Pharmacology. Drug treatments
pre-polarization
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Signal Processing, Computer-Assisted
Sodium Chloride - chemistry
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Summary:The potential for using pre‐polarized liquids as contrast agents in vivo is investigated and the feasibility of the method demonstrated. In this study we show the enhancement obtained following intravenous delivery of pre‐polarized saline into the antecubital vein of a volunteer. This form of contrast agent provides signal gain on time scales commensurate with its T1 and allows repeated doses to be administered, thus making alternate acquisitions of data with and without enhancement practicable. Copyright © 1999 John Wiley & Sons, Ltd.
ISSN:0952-3480
1099-1492
DOI:10.1002/(SICI)1099-1492(199910)12:6<381::AID-NBM574>3.0.CO;2-9