Measles History and Atopic Diseases: A Population-Based Cross-sectional Study

• Published in: JAMA : the journal of the American Medical Association 2000-01, Vol.283 (3), p.343-346
• Main Authors: Paunio, Mikko, Heinonen, Olli P, Virtanen, Martti, Leinikki, Pauli, Patja, Annamari, Peltola, Heikki
• Format: Article
• Language: English
• Subjects: Adolescent; Allergic diseases; Allergies; Asthma - epidemiology; Asthma - virology; Biological and medical sciences; Child; Child, Preschool; Cross-Sectional Studies; Data Collection; Eczema - epidemiology; Eczema - virology; Finland - epidemiology; General aspects; Human viral diseases; Humans; Hypersensitivity, Immediate - epidemiology; Hypersensitivity, Immediate - virology; Immunopathology; Infant; Infectious diseases; Measles; Measles - epidemiology; Measles - immunology; Measles virus; Medical sciences; Prevalence; Rhinitis, Allergic, Perennial - epidemiology; Rhinitis, Allergic, Perennial - virology; Vaccines; Viral diseases; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
• ISSN: 0098-7484; 1538-3598
• DOI: 10.1001/jama.283.3.343

CONTEXT Many recent cross-sectional studies have suggested that lack of early exposure to communicable diseases, including measles, in affluent countries may have increased rates of atopic disease. OBJECTIVE To study the association between natural measles infection and atopy. DESIGN AND SETTING Cross-sectional nationwide study in Finland using data gathered between November 1, 1982, and June 30, 1986. SUBJECTS A total of 547,910 individuals aged 14 months to 19 years who at the time of measles-mumps-rubella (MMR) vaccination had relevant information collected on the occurrence of measles and allergic rhinitis, eczema, and asthma. MAIN OUTCOME MEASURES Lifetime occurrence of atopic manifestations in subjects who had had measles compared with those who had not, expressed as age-specific and age-adjusted prevalence ratios. RESULTS The age-adjusted prevalence ratio of atopic manifestations among those who had had measles (n = 20,690) compared with those who had not (n = 527,220) was 1.32 (95% confidence interval [CI], 1.27-1.36) for eczema, 1.41 (95% CI, 1.33-1.49) for rhinitis, and 1.67 (95% CI, 1.54-1.79) for asthma. The positive association between measles and atopy was evident at all ages, in both urban and rural dwellers, and among subjects with many or few contacts at home or in day care. CONCLUSIONS Based on our data, measles and atopy occur more frequently together than expected, which does not support the hypothesis that experiencing natural measles infection offers protection against atopic disease.