CH/π interaction in the conformation of peptides. A database study

A study was carried out, with use of the Cambridge Structural Database, to examine the role of the CH/pi interaction in the conformation of peptides. A number of short intramolecular CH/pi distances have been shown in the crystal structure of peptides bearing at least an aromatic residue in the sequ...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 1999-09, Vol.7 (9), p.2021-2026
Main Authors: UMEZAWA, Y, TSUBOYAMA, S, TAKAHASHI, H, UZAWA, J, NISHIO, M
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Aminoacids, peptides. Hormones. Neuropeptides
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Databases, Factual
Fundamental and applied biological sciences. Psychology
Peptides - chemistry
Protein Conformation
Proteins
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Summary:A study was carried out, with use of the Cambridge Structural Database, to examine the role of the CH/pi interaction in the conformation of peptides. A number of short intramolecular CH/pi distances have been shown in the crystal structure of peptides bearing at least an aromatic residue in the sequence. The molecular structure in the crystal was inspected individually to know whether the conformation is merely a consequence of the so-called packing forces, or the CH/pi interaction plays a role. It has been demonstrated that the CH/pi interaction constitutes one of the key factors in controlling the conformation of peptides.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(99)00123-6