Description of Japanese twins with cleft lip, cleft palate, or both

Cleft lip and palate is relatively common among congenital external malformations; however, the pathogenesis of this condition remains unclear. Cleft lip and palate has long been considered to be a multifactorial hereditary disease in which not only genetic factors, but also environmental factors, m...

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Bibliographic Details
Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2000-01, Vol.89 (1), p.6-8
Main Authors: Natsume, Nagato, Sato, Fumihiko, Hara, Kouji, Kawai, Tsuyoshi, Ogi, Nobumi
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cleft Lip - ethnology
Cleft Lip - genetics
Cleft Palate - ethnology
Cleft Palate - genetics
Dentistry
Diseases in Twins - ethnology
Diseases in Twins - genetics
Female
Humans
Incidence
Japan - epidemiology
Male
Medical sciences
Non tumoral diseases
Otorhinolaryngology. Stomatology
Twins, Monozygotic
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Cleft lip and palate is relatively common among congenital external malformations; however, the pathogenesis of this condition remains unclear. Cleft lip and palate has long been considered to be a multifactorial hereditary disease in which not only genetic factors, but also environmental factors, may be related in a complex manner. We have been studying the pathogenesis of cleft lip and palate in Japan and report here on some recent findings. We reviewed 32 pairs of Japanese monozygotic twins who had cleft lip and palate and compared these twins with non-twins who had cleft lip and palate in order to elucidate genetic factors that may cause this malformation.
ISSN:1079-2104
1528-395X
DOI:10.1016/S1079-2104(00)80004-9