Insulin and glucagon secretion in patients with slowly progressing autoimmune diabetes (LADA)

To metabolically characterize patients with slowly progressing autoimmune diabetes (LADA) of short duration we measured insulin, C peptide, and glucagon responses to glucose and arginine at three blood glucose levels (fasting and 14 and 28 mmol/L) in 11 patients with LADA, 11 patients with type 2 di...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2000, Vol.85 (1), p.76-80
Main Authors: CARLSSON, A, SUNDKVIST, G, GROOP, L, TUOMI, T
Format: Article
Language:English
Subjects:
Adult
Arginine
Biological and medical sciences
Blood Glucose - metabolism
C-Peptide - blood
Diabetes Mellitus, Type 1 - metabolism
Diabetes Mellitus, Type 2 - metabolism
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Glucagon - blood
Glucose
Humans
Insulin - blood
Male
Medical sciences
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Summary:To metabolically characterize patients with slowly progressing autoimmune diabetes (LADA) of short duration we measured insulin, C peptide, and glucagon responses to glucose and arginine at three blood glucose levels (fasting and 14 and 28 mmol/L) in 11 patients with LADA, 11 patients with type 2 diabetes, and 14 healthy control subjects matched for age and body mass index. The acute insulin response to arginine was impaired in LADA vs. type 2 diabetes at all glucose levels, with the greatest impairment in the maximally stimulated insulin concentrations (P
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.85.1.76