Possible virulence factors of Staphylococcus sciuri

Staphylococcus sciuri is an opportunistic pathogen of controversial clinical significance. The factors that contribute to colonization and/or infection caused by this bacterium have not been studied intensively so far. The present research was carried out in order to study the presence of potential...

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Bibliographic Details
Published in:FEMS microbiology letters 2001-05, Vol.199 (1), p.47-53
Main Authors: Stepanovic, S, Vukovic, D, Trajkovic, V, Samardzic, T, Cupic, M, Svabic-Vlahovic, M
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacterial diseases
Bacterial Proteins - metabolism
Bacteriology
Biocompatibility
biofilm
Biofilms
Biological and medical sciences
Colonization
Cytotoxicity
Deoxyribonuclease
deoxyribonucleases
Dogs
Exotoxins
Experimental bacterial diseases and models
Fundamental and applied biological sciences. Psychology
Hemagglutination
Hemolysin Proteins - metabolism
Hemolysins
humans
In vivo methods and tests
Infectious diseases
Macrophages
Macrophages - immunology
Medical sciences
Microbiology
Nitric oxide
Nitric Oxide - biosynthesis
Opportunist infection
Pathogenicity
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
pathogens
Proteolysis
Rats
Staphylococcal Infections - microbiology
Staphylococcus
Staphylococcus - immunology
Staphylococcus - pathogenicity
Staphylococcus sciuri
Toxicity
Virulence
Virulence factors
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Summary:Staphylococcus sciuri is an opportunistic pathogen of controversial clinical significance. The factors that contribute to colonization and/or infection caused by this bacterium have not been studied intensively so far. The present research was carried out in order to study the presence of potential virulence factors in 121 human and animal isolates of this bacterium. Isolates were examined for biofilm formation, hemagglutination, presence of clumping factor, production of spreading factors and exotoxins, cytotoxicity and capacity to stimulate nitric oxide production. The results showed that S. sciuri is highly capable of biofilm production, that it displays strong proteolytic and DNase activities, produces hemolysins and stimulates nitric oxide production by rat macrophages. Although the present study showed existence of a wide spectrum of possible virulence determinants of S. sciuri, their exact contribution to virulence of this bacterium in vivo remains to be determined.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.2001.tb10649.x