Treatment outcome of single or hypofractionated single-isocentric stereotactic irradiation (STI) using a linear accelerator for intracranial arteriovenous malformation

We investigated the use of hypofractionated stereotactic radiotherapy (HFSR) to reduce adverse radiation effects in comparison to single-fraction stereotactic radiosurgery (SRS) for intracranial arteriovenous malformations (AVMs). This study includes 53 intracranial AVMs treated between 1991-1998. H...

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Bibliographic Details
Published in:Radiotherapy and oncology 2001-06, Vol.59 (3), p.323-328
Main Authors: Aoyama, H, Shirato, H, Nishioka, T, Kagei, K, Onimaru, R, Suzuki, K, Ushikoshi, S, Houkin, K, Kuroda, S, Abe, H, Miyasaka, K
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Arteriovenous Fistula - congenital
Arteriovenous Fistula - radiotherapy
Arteriovenous Fistula - surgery
Child
Child, Preschool
Confidence Intervals
Female
Follow-Up Studies
Humans
Intracranial Arteriovenous Malformations - radiotherapy
Intracranial Arteriovenous Malformations - surgery
Male
Middle Aged
Particle Accelerators - instrumentation
Radiosurgery
Risk Factors
Treatment Outcome
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Summary:We investigated the use of hypofractionated stereotactic radiotherapy (HFSR) to reduce adverse radiation effects in comparison to single-fraction stereotactic radiosurgery (SRS) for intracranial arteriovenous malformations (AVMs). This study includes 53 intracranial AVMs treated between 1991-1998. HFSR was selected for 26 AVMs with a maximum diameter > or 2.5 cm or at eloquent area. Twenty-seven patients were treated with SRS (18 AVMs < 2.5 cm at non-eloquent area, nine patients who were unfit for prolonged ring-wearing). The most frequent minimum dose (Dmin) was 20 Gy for SRS and 28 Gy for HFSR in four fractions. The mean follow-up duration was 34.6 months for SRS and 35.4 months for HFSR. As a whole, the 3 and 5-year actuarial obliteration rates were 64 and 92%. Age
ISSN:0167-8140
DOI:10.1016/s0167-8140(01)00303-6