RENAL TUBULAR CELL NECROSIS AND APOPTOSIS IN TRANSPLANTED KIDNEYS

Renal wedge biopsies were taken from donors' kidneys immediately at the end of cold ischaemia and 30min after transplantation in 11 cases. Five renal grafts showed immediate and six showed delayed renal function clinically. The ratio of apoptotic and necrotic renal tubular cells and Ki67 activi...

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Bibliographic Details
Published in:Cell biology international 2001-03, Vol.25 (3), p.267-270
Main Authors: Toronyi, E., Lord, R., Bowen, I.D., Perner, F., Szende, B.
Format: Article
Language:English
Subjects:
Apoptosis
Biopsy
Humans
Ki-67 Antigen - metabolism
Ki67 activity
Kidney Transplantation - pathology
Kidney Tubular Necrosis, Acute - metabolism
Kidney Tubular Necrosis, Acute - pathology
Kidney Tubular Necrosis, Acute - physiopathology
Necrosis
renal transplantation
renal tubular epithelium
Time Factors
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Summary:Renal wedge biopsies were taken from donors' kidneys immediately at the end of cold ischaemia and 30min after transplantation in 11 cases. Five renal grafts showed immediate and six showed delayed renal function clinically. The ratio of apoptotic and necrotic renal tubular cells and Ki67 activity was determined in both biopsies. Necrotic and apoptotic as well as proliferating renal tubular cells were seen in all samples. Both apoptotic and proliferative activity was decreased in samples taken 30min after transplantation in cases of immediate renal function compared to the samples taken before transplantation. This phenomenon was not observed in cases of delayed renal function.
ISSN:1065-6995
1095-8355
DOI:10.1006/cbir.2000.0620