Efficient Transfer of Information from Hexitol Nucleic Acids to RNA during Nonenzymatic Oligomerization

Hexitol nucleic acids (HNAs) are DNA analogues that contain the standard nucleoside bases attached to a phosphorylated 1,5-anhydrohexitol backbone. We find that HNAs support efficient information transfer in nonenzymatic template-directed reactions. HNA heterosequences appeared to be superior to the...

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Bibliographic Details
Published in:Journal of the American Chemical Society 1999-06, Vol.121 (25), p.5856-5859
Main Authors: Kozlov, Igor A, De Bouvere, Bart, Van Aerschot, Arthur, Herdewijn, Piet, Orgel, Leslie E
Format: Article
Language:English
Subjects:
1,5-anhydrohexitol
Chromatography, High Pressure Liquid
Directed Molecular Evolution
DNA
Evolution, Molecular
Exobiology
Guanosine Monophosphate - analogs & derivatives
Guanosine Monophosphate - chemistry
Hexitol nucleic acids
Molecular Structure
Nucleic Acids - chemistry
nucleoside-5'-phosphoro-2-methyl imidazolide
nucleoside-5'-phosphoro-2-methyl imidazolides
Nucleosides - chemistry
oligonucleotides
Oligonucleotides - chemical synthesis
Polymers - chemical synthesis
Polymers - chemistry
RNA - chemistry
Space life sciences
Sugar Alcohols - chemistry
Templates, Genetic
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Summary:Hexitol nucleic acids (HNAs) are DNA analogues that contain the standard nucleoside bases attached to a phosphorylated 1,5-anhydrohexitol backbone. We find that HNAs support efficient information transfer in nonenzymatic template-directed reactions. HNA heterosequences appeared to be superior to the corresponding DNA heterosequences in facilitating synthesis of complementary oligonucleotides from nucleoside-5‘-phosphoro-2-methyl imidazolides.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja990440u