The DNA Sequence of the Simian Varicella Virus Genome

In nonhuman primates, simian varicella virus (SVV) causes a natural disease which is clinically similar to human varicella-zoster virus (VZV) infections. The SVV and VZV genomes are similar in size and structure and share extensive DNA homology. This report presents the complete DNA sequence of the...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2001-05, Vol.284 (1), p.123-130
Main Authors: Gray, Wayne L., Starnes, Ben, White, Michael W., Mahalingam, Ravi
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
Chromosome Mapping
Cytosine - chemistry
DNA sequence
DNA, Viral - chemistry
Erythrocebus patas
Genome, Viral
Guanine - chemistry
nonhuman primate herpesvirus
Open Reading Frames
Sequence Analysis, DNA
Simian varicella virus
Tandem Repeat Sequences
Varicella-zoster virus
Varicellovirus - genetics
Virus Latency - genetics
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Summary:In nonhuman primates, simian varicella virus (SVV) causes a natural disease which is clinically similar to human varicella-zoster virus (VZV) infections. The SVV and VZV genomes are similar in size and structure and share extensive DNA homology. This report presents the complete DNA sequence of the SVV genome. SVV DNA is 124,138 bp in size, 746 bp shorter than VZV DNA, and 40.4% G + C. The viral genome includes a 104,104-bp unique long component bracketed by 8-bp inverted repeat sequences and a short component composed of a 4904-bp unique short region bracketed by 7557-bp inverted repeat sequences. A total of 69 distinct SVV open reading frames (ORFs) were identified, including three that are duplicated within the inverted repeats of the short component. Each of the SVV ORFs shares extensive homology to a corresponding VZV gene. The only major difference between SVV and VZV DNA occurs at the leftward terminus. SVV lacks a VZV ORF 2 homolog. In addition, SVV encodes an 882-bp ORF A that is absent in VZV, but has homology to the SVV and VZV ORF 4. The results of this study confirm the relatedness of SVV and VZV and provide further support for simian varicella as a model to investigate VZV pathogenesis and latency.
ISSN:0042-6822
1096-0341
DOI:10.1006/viro.2001.0912