Association of remnant-like particle cholesterol with coronary artery disease in patients with normal total cholesterol levels

Background Limited information is available as to whether there is a difference in the association of lipid and fibrinolytic variables with coronary artery disease according to the presence or absence of elevated serum total cholesterol. We examined the levels of various lipid and fibrinolytic varia...

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Bibliographic Details
Published in:The American heart journal 2000-02, Vol.139 (2), p.305-310
Main Authors: Masuoka, Hiroshi, Kamei, Shigeru, Wagayama, Hidetaka, Ozaki, Morihiro, Kawasaki, Atsushi, Tanaka, Tsuyoshi, Kitamura, Masami, Katoh, Shigeki, Shintani, Uichiro, Misaki, Moriharu, Sugawa, Masahiro, Ito, Masaaki, Nakano, Takeshi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cardiology. Vascular system
Cholesterol - blood
Cholesterol, HDL
Coronary Disease - blood
Coronary heart disease
Fibrinolysis
Heart
Humans
Hypercholesterolemia - blood
Medical sciences
Middle Aged
Retrospective Studies
Uric Acid - blood
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Summary:Background Limited information is available as to whether there is a difference in the association of lipid and fibrinolytic variables with coronary artery disease according to the presence or absence of elevated serum total cholesterol. We examined the levels of various lipid and fibrinolytic variables including remnant-like particle cholesterol (RLP-C). RLP-C is a recently established simple assay method for the estimation of triglyceride-rich lipoprotein remnants. Methods and Results Levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), triglyceride, lipoprotein (a), RLP-C, uric acid, blood glucose, tissue plasminogen activator, tissue plasminogen activator inhibitor type 1, antithrombin III, and protein C were measured in 208 patients who underwent diagnostic coronary angiograms. Of these 208 patients, 57 were hypercholesterolemic (≥220 mg/dL) and 151 were normocholesterolemic. HDL-C showed significant differences between patients with and those without angiographically determined coronary artery stenosis in both hypercholesterolemic and normocholesterolemic patients ( P =.0025 and P =.0003, respectively). Both RLP-C and uric acid showed significant differences only in the normocholesterolemic subgroup ( P =.0006 and P = .0060, respectively). This difference in uric acid was not significant by multivariable analysis. The ratio of RLP-C/HDL-C was demonstrated to be highly significantly ( P
ISSN:0002-8703
1097-6744
DOI:10.1016/S0002-8703(00)90240-0