Acyclovir-containing liposomes for potential ocular delivery: Corneal penetration and absorption

The in vitro corneal penetration and in vivo corneal absorption of acyclovir from an acyclovir-containing liposome system were investigated. Results of in vitro corneal penetration demonstrated that positively charged liposomes resulted in a penetration rate lower than those of negatively charged li...

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Bibliographic Details
Published in:Journal of controlled release 2000-01, Vol.63 (1-2), p.135-140
Main Authors: Law, S.L, Huang, K.J, Chiang, C.H
Format: Article
Language:English
Subjects:
Absorption
Acyclovir
Acyclovir - administration & dosage
Acyclovir - pharmacokinetics
Administration, Topical
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - administration & dosage
Antiviral Agents - pharmacokinetics
Aqueous Humor - metabolism
Biological and medical sciences
Cornea - metabolism
Corneal penetration
Drug Carriers
General pharmacology
Liposomes
Male
Medical sciences
Ophthalmic Solutions
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Rabbits
Surface charge
Surface Properties
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Summary:The in vitro corneal penetration and in vivo corneal absorption of acyclovir from an acyclovir-containing liposome system were investigated. Results of in vitro corneal penetration demonstrated that positively charged liposomes resulted in a penetration rate lower than those of negatively charged liposomes and free acyclovir in solution. An in vivo study indicated that the extent of acyclovir absorption from positively charged liposomes was higher that those from negatively charged liposomes and free acyclovir. The acyclovir concentration in the cornea after administration of positively charged liposomes showed that an acyclovir deposition in the cornea was greater than those of negatively charged liposomes and free acyclovir. From morphological observation of the cornea surface treated with liposomes, it was suggested that positively charged liposomes formed a completely coated layer on the cornea surface. These liposomes would bind intimately on the cornea surface, leading to an increase of residence time. Therefore, positively charged liposomes resulted in an increase of acyclovir (ACV) absorption.
ISSN:0168-3659
1873-4995
DOI:10.1016/S0168-3659(99)00192-3