High- or Low-Salt Diet From Weaning to Adulthood: Effect on Insulin Sensitivity in Wistar Rats

ABSTRACTBecause of conflicting results in the literature, further studies are needed to confirm an association between the degree of salt consumption and insulin sensitivity. The aim of this study was to measure insulin sensitivity in rats fed from weaning to adulthood with a low (LSD), normal (NSD)...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2000-01, Vol.35 (1, Part 2 Suppl), p.424-424
Main Authors: Prada, Patrícia de O, Okamoto, Maristella M, Furukawa, Luzia Naôko S, Machado, Ubiratan Fabres, Heimann, Joel C, Dolnikoff, Miriam Sterman
Format: Article
Language:English
Subjects:
Aging - physiology
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Animals
Antihypertensive Agents - pharmacology
Biological Transport - drug effects
Body Weight
Captopril - pharmacology
Diet, Sodium-Restricted
Glucose - pharmacokinetics
Glucose Transporter Type 4
Hyperinsulinism - physiopathology
Insulin Resistance - physiology
Losartan - pharmacology
Male
Monosaccharide Transport Proteins - analysis
Muscle Proteins
Rats
Rats, Wistar
Sodium Chloride, Dietary - pharmacology
Weaning
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Summary:ABSTRACTBecause of conflicting results in the literature, further studies are needed to confirm an association between the degree of salt consumption and insulin sensitivity. The aim of this study was to measure insulin sensitivity in rats fed from weaning to adulthood with a low (LSD), normal (NSD), or high (HSD) salt diet. Body weight, carcass lipid content, blood glucose, nonesterified fatty acids, plasma insulin, plasma renin activity, and a glucose transporter (GLUT4) were measured. A euglycemic hyperinsulinemic clamp was used in 52 anesthetized rats. Body weight was higher in rats on LSD than in those on NSD (P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.35.1.424