Skin hyporeactivity in relation to patch testing

False‐negative patch tests are clinically relevant. Skin hyporeactivity has been suggested as one possible cause. Evidence supports that failure to respond to a specific antigen might be due either to a faulty immune response, a defective inflammatory response or both. Thus, skin hyporeactivity may...

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Bibliographic Details
Published in:Contact dermatitis 2000-01, Vol.42 (1), p.1-4
Main Authors: Koehler, Almuth M., Maibach, Howard I.
Format: Article
Language:English
Subjects:
Allergic diseases
anergy
Biological and medical sciences
excited skin syndrome
False Negative Reactions
Humans
Hypersensitivity, Delayed - diagnosis
Hypersensitivity, Delayed - immunology
Immune Tolerance
Immunopathology
Medical sciences
patch testing technique
Patch Tests
Skin - immunology
Skin allergic diseases. Stinging insect allergies
skin hyperreactivity
skin hyporeactivity
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Summary:False‐negative patch tests are clinically relevant. Skin hyporeactivity has been suggested as one possible cause. Evidence supports that failure to respond to a specific antigen might be due either to a faulty immune response, a defective inflammatory response or both. Thus, skin hyporeactivity may have clinical relevance in routine patch testing. Articles on this topic are infrequent and there is no index keyword for skin hyporeactivity as this phenomenon is poorly defined and investigated. This article summarizes several observations of skin hyporeactivity, reviews theories of possible mechanisms and discusses further consequences.
ISSN:0105-1873
1600-0536
DOI:10.1034/j.1600-0536.2000.042001001.x