Brain-invasive meningioma in a 16-month-old boy

A previously well 16-month-old boy presented to Sydney Children's Hospital with generalised seizures. There was no history of neurofibromatosis and no family history. Imaging revealed a well-demarcated, frontal intracranial mass at the grey-white matter junction with surrounding oedema. At oper...

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Bibliographic Details
Published in:Pathology 2001-05, Vol.33 (2), p.252-256
Main Authors: SYMONS, Patricia, TOBIAS, Vivienne, PEREIRA, John, VONAU, Marianne
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain Neoplasms - chemistry
Brain Neoplasms - secondary
Brain Neoplasms - surgery
Humans
Immunoenzyme Techniques
Infant
Magnetic Resonance Imaging
Male
Medical sciences
Meningeal Neoplasms - chemistry
Meningeal Neoplasms - pathology
Meningeal Neoplasms - surgery
Meningioma - chemistry
Meningioma - secondary
Meningioma - surgery
Mucin-1 - analysis
Neoplasm Invasiveness - pathology
Neurology
Phosphopyruvate Hydratase - analysis
Seizures - etiology
Tumors of the nervous system. Phacomatoses
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Summary:A previously well 16-month-old boy presented to Sydney Children's Hospital with generalised seizures. There was no history of neurofibromatosis and no family history. Imaging revealed a well-demarcated, frontal intracranial mass at the grey-white matter junction with surrounding oedema. At operation, the tumour was adherent to the underlying brain on its deep aspect but superficially connected to the dura. There was an associated peritumoural cyst. The tumour was biopsied for intra-operative frozen section opinion and excised in its entirety. The specimen consisted of a 25 x 25 x 17 mm nodule of firm cream tissue and separate fragments. Histologically, the tumour was a meningioma with frequent mitoses, necrosis and brain invasion. Optimal treatment, in view of the recurrence risk, includes complete excision and postoperative irradiation. The latter was deferred because of the young age. At follow-up at 26 months, the child was well and free of disease on MRI scan. Paediatric meningiomas are rare, with very few brain-invasive examples in reported series. In infants and young children, few meningiomas have been reported. There are several notable differences between meningiomas in children and adults. This report illustrates these differences.
ISSN:0031-3025
1465-3931
DOI:10.1080/00313020120038566