Infections, inflammation, and the risk of coronary heart disease

The role of infections and inflammation in the pathophysiology of coronary heart disease is emerging. We studied the independent and joint effects of these 2 components on coronary risk. We measured baseline levels of C-reactive protein (CRP) and antibodies to adenovirus, enterovirus, cytomegaloviru...

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Published in:Circulation (New York, N.Y.) N.Y.), 2000-01, Vol.101 (3), p.252-257
Main Authors: ROIVAINEN, M, VIIK-KAJANDER, M, PALOSUO, T, TOIVANEN, P, LEINONEN, M, SAIKKU, P, TENKANEN, L, MANNINEN, V, HOVI, T, MÄNTTÄRI, M
Format: Article
Language:English
Subjects:
Adult
Antibodies, Viral - blood
Biological and medical sciences
C-Reactive Protein - analysis
Cardiology. Vascular system
Chlamydia Infections - complications
Chlamydophila pneumoniae
Coronary Disease - etiology
Coronary heart disease
Heart
Herpes Simplex - complications
Humans
Inflammation - complications
Medical sciences
Middle Aged
Risk Factors
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Summary:The role of infections and inflammation in the pathophysiology of coronary heart disease is emerging. We studied the independent and joint effects of these 2 components on coronary risk. We measured baseline levels of C-reactive protein (CRP) and antibodies to adenovirus, enterovirus, cytomegalovirus, and herpes simplex virus as well as to Chlamydia pneumoniae (Cpn) and Helicobacter pylori in 241 subjects who suffered either myocardial infarction or coronary death during the 8.5-year trial in the Helsinki Heart Study, a coronary primary prevention trial. The 241 controls in this nested case-control study were subjects who completed the study without coronary events. Antibody levels to herpes simplex type I (HSV-1) and to Cpn were higher in cases than in controls, whereas the distributions of antibodies to other infectious agents were similar. Mean CRP was higher in cases (4.4 versus 2.0 mg/L; P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.101.3.252