Insertion/deletion polymorphism in the angiotensin-converting enzyme gene affects heart weight

Angiotensin (Ang) II, a major regulatory factor for left ventricular mass, is generated from Ang I by ACE. ACE levels are associated with an insertion/deletion (I/D) polymorphism in the ACE gene. The ACE polymorphism should result in varied Ang II concentrations and hence affect left ventricular mas...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2000-01, Vol.101 (2), p.148-151
Main Authors: NAKAHARA, K.-I, MATSUSHITA, S, MATSUOKA, H, INAMATSU, T, NISHINAGA, M, YONAWA, M, AONO, T, ARAI, T, EZAKI, Y, ORIMO, H
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging - physiology
Biological and medical sciences
Cardiology. Vascular system
DNA Transposable Elements - physiology
Female
Gene Deletion
Genotype
Heart
Heart - anatomy & histology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Hypertension - genetics
Hypertension - pathology
Male
Medical sciences
Organ Size - physiology
Peptidyl-Dipeptidase A - genetics
Phenotype
Polymorphism, Genetic - genetics
Polymorphism, Genetic - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Angiotensin (Ang) II, a major regulatory factor for left ventricular mass, is generated from Ang I by ACE. ACE levels are associated with an insertion/deletion (I/D) polymorphism in the ACE gene. The ACE polymorphism should result in varied Ang II concentrations and hence affect left ventricular mass. We therefore investigated whether ACE genotype is a predictor of heart weight. From 693 consecutive patients autopsied between 1994 and 1998 in our hospital, patients with valvular disease, myocardial infarction, or cardiomyopathy were excluded. The remaining 443 autopsy patients were the subjects of our study. The heart weight at autopsy was corrected for body surface area. Genomic DNA was purified from the kidney, and ACE genotype was determined by polymerase chain reaction. Heart weight in the DD genotype (249. 9+/-49.9 g/m(2)) was significantly higher than that in the ID (230. 0+/-51.2 g/m(2); P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.101.2.148