Diffuse muscular haemorrhage as presenting sign of juvenile systemic lupus erythematosus and lupus anticoagulant hypoprothrombinaemia syndrome

Lupus anticoagulants are closely related to systemic lupus erythemathosus (SLE) and to thrombotic events. We describe a 12 year‐old girl with a bilateral intramuscular haemorrhage of the gastrocnemius muscles as her main initial presentation of juvenile SLE. Laboratory work‐up revealed lupus anticoa...

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Published in:Rheumatology (Oxford, England) England), 2001-05, Vol.40 (5), p.585-587
Main Authors: Yacobovich, J. R., Uziel, Y., Friedman, Z., Radnay, J., Wolach, B.
Format: Article
Language:English
Subjects:
Antiphospholipid Syndrome - diagnosis
Biological and medical sciences
Child
Diagnosis, Differential
Female
Haemorrhage
Hemorrhage - etiology
Humans
Lupus anticoagulant–hypoprothrombinaemia syndrome
Lupus Coagulation Inhibitor - analysis
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - drug therapy
Magnetic Resonance Imaging
Medical sciences
Muscle, Skeletal - pathology
Paediatric
Prednisone - therapeutic use
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Syndrome
Systemic lupus erythematosus
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Wolach, B.
description Lupus anticoagulants are closely related to systemic lupus erythemathosus (SLE) and to thrombotic events. We describe a 12 year‐old girl with a bilateral intramuscular haemorrhage of the gastrocnemius muscles as her main initial presentation of juvenile SLE. Laboratory work‐up revealed lupus anticoagulant‐hypoprothrombinaemia syndrome (LAHS) with very low levels of factor II due to autoantibodies. She showed a good initial clinical and laboratory response to prednisone therapy, however steroid dependency developed. To the best of our knowledge, this is the first case reported of juvenile SLE presenting with LAHS.
doi_str_mv 10.1093/rheumatology/40.5.585
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source Oxford Journals Online; Alma/SFX Local Collection
subjects Antiphospholipid Syndrome - diagnosis
Biological and medical sciences
Child
Diagnosis, Differential
Female
Haemorrhage
Hemorrhage - etiology
Humans
Lupus anticoagulant–hypoprothrombinaemia syndrome
Lupus Coagulation Inhibitor - analysis
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - drug therapy
Magnetic Resonance Imaging
Medical sciences
Muscle, Skeletal - pathology
Paediatric
Prednisone - therapeutic use
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Syndrome
Systemic lupus erythematosus
title Diffuse muscular haemorrhage as presenting sign of juvenile systemic lupus erythematosus and lupus anticoagulant hypoprothrombinaemia syndrome
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