Autoantibody recognition of COOH-terminal epitopes of GAD65 marks the risk for insulin requirement in adult-onset diabetes mellitus

Some type 2 diabetic subjects develop secondary failure to sulphonylurea treatment and require insulin therapy. To test the diagnostic sensitivity and specificity of epitopes of GAD65 autoantibodies (GAD65Ab) for insulin requirement, in patients with latent autoimmune diabetes of the adult, we studi...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2000, Vol.85 (1), p.309-316
Main Authors: FALORNI, A, GAMBELUNGHE, G, FORINI, F, KASSI, G, COSENTINO, A, CANDELORO, P, BOLLI, G. B, BRUNETTI, P, CALCINARO, F
Format: Article
Language:English
Subjects:
Adult
Aged
Autoantibodies - immunology
Biological and medical sciences
Biomarkers
C-Peptide - genetics
Cross-Sectional Studies
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - immunology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Epitopes - immunology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Follow-Up Studies
Glutamate Decarboxylase - immunology
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - therapeutic use
Insulin - administration & dosage
Insulin - therapeutic use
Iodide Peroxidase - immunology
Isoenzymes - immunology
Italy - epidemiology
Male
Medical sciences
Middle Aged
Risk Factors
Time Factors
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Description
Summary:Some type 2 diabetic subjects develop secondary failure to sulphonylurea treatment and require insulin therapy. To test the diagnostic sensitivity and specificity of epitopes of GAD65 autoantibodies (GAD65Ab) for insulin requirement, in patients with latent autoimmune diabetes of the adult, we studied 569 adult subjects with a clinical diagnosis of type 2 diabetes mellitus. All the patients had been initially treated with hypoglycemic agents and/or diet for at least 1 yr. The presence of GAD65Ab (61/569, 10.7%) depended on insulin therapy (P
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.85.1.309