Expression of the proteoglycan SPOCK during mouse embryo development

SPOCK is a modular proteoglycan, with homology with proteins involved in cell adhesion processes and neurogenesis. We have previously shown that SPOCK transcripts predominate in the adult mouse brain. Here, we report its expression during mouse embryonic development by in situ hybridization, and imm...

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Bibliographic Details
Published in:Mechanisms of development 2000-02, Vol.90 (2), p.317-321
Main Authors: Charbonnier, F, Chanoine, C, Cifuentes-Diaz, C, Gallien, C.L, Rieger, F, Alliel, P.M, Périn, J.P
Format: Article
Language:English
Subjects:
Animals
Central nervous system
Chondroitin
Dorsal root ganglia
Embryonic and Fetal Development
Gene Expression
Heparan
Immunohistochemistry
In situ hybridization
Mice
Mouse
Nervous System - embryology
Neuron
Peripheral nervous system
Proteoglycan
Proteoglycans - genetics
Proteoglycans - metabolism
Spinal cord
Spock
Testican
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Summary:SPOCK is a modular proteoglycan, with homology with proteins involved in cell adhesion processes and neurogenesis. We have previously shown that SPOCK transcripts predominate in the adult mouse brain. Here, we report its expression during mouse embryonic development by in situ hybridization, and immunocytochemistry. SPOCK is actively expressed at the onset of neurogenesis during periods of neuron migration and axonal outgrowth. At a later developmental stage, its expression is particularly prevalent within developing synaptic fields. In the peripheral nervous system, SPOCK expression is also developmentally regulated particularly in dorsal root ganglion neurons.
ISSN:0925-4773
1872-6356
DOI:10.1016/S0925-4773(99)00255-5