Effect of vaccination on the potentiation of porcine reproductive and respiratory syndrome virus (PRRSV)-induced pneumonia by Mycoplasma hyopneumoniae

• Published in: Vaccine 2000-01, Vol.18 (13), p.1244-1252
• Main Authors: Thacker, Eileen L., Thacker, Brad J., Young, Theresa F., Halbur, Patrick G.
• Format: Article
• Language: English
• Subjects: Animals; Antibodies, Bacterial - biosynthesis; Antibodies, Bacterial - blood; Antibody Specificity; Bacterial Vaccines - immunology; Bacterial Vaccines - therapeutic use; Biological and medical sciences; Bronchoalveolar Lavage Fluid - immunology; Experimental viral diseases and models; Immunoglobulin G - biosynthesis; Immunoglobulin G - blood; Infectious diseases; Lung - immunology; Lung - microbiology; Lung - pathology; Lung - virology; Medical sciences; Mycoplasma - immunology; Mycoplasma - isolation & purification; Mycoplasma hyopneumoniae; Pneumonia of Swine, Mycoplasmal - immunology; Pneumonia of Swine, Mycoplasmal - prevention & control; Pneumonia of Swine, Mycoplasmal - veterinary; Pneumonia, Viral - immunology; Pneumonia, Viral - veterinary; Porcine Reproductive and Respiratory Syndrome - immunology; Porcine Reproductive and Respiratory Syndrome - microbiology; Porcine Reproductive and Respiratory Syndrome - prevention & control; Porcine respiratory and reproductive syndrome virus; Porcine respiratory and reproductive syndrome virus - immunology; Porcine respiratory and reproductive syndrome virus - isolation & purification; PRRSV; Random Allocation; Swine; Swine Diseases - immunology; Swine Diseases - microbiology; Swine Diseases - prevention & control; Vaccination; Viral diseases; Viral Vaccines - immunology; Viral Vaccines - therapeutic use
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/S0264-410X(99)00395-3

Porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae are frequently isolated pathogens from pigs with respiratory disease. A previous study conducted in our laboratory found that infection with M. hyopneumoniae increased the duration and severity of respiratory disease induced by PRRSV. The purpose of this experiment was to determine whether vaccination against M. hyopneumoniae and/or PRRSV decreased the enhancement of PRRSV-induced pneumonia. Both M. hyopneumoniae bacterin and PRRSV vaccine decreased the severity of clinical respiratory disease. Infection or vaccination with PRRSV appeared to decrease the efficacy of the M. hyopneumoniae bacterin. Vaccination with M. hyopneumoniae bacterin decreased the potentiation of PRRSV-induced pneumonia observed in the dual infected pigs. However, PRRSV vaccination in combination with M. hyopneumoniae bacterin eliminated this benefit and the amount of pneumonia induced by PRRSV increased. PRRSV vaccine alone did not decrease the potentiation of PRRSV pneumonia by M. hyopneumoniae.