Epstein-Barr virus specific salivary antibodies as related to stress caused by examinations

Epstein‐Barr virus (EBV) is prevalent in 90% of the population. After primary infection it remains in a latent state and the majority of the virus carriers are asymptomatic during their life. Among the immunocompromized patients such as organ and bone marrow transplant recipients, individuals lackin...

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Bibliographic Details
Published in:Journal of medical virology 2001-06, Vol.64 (2), p.149-156
Main Authors: Sarid, O., Anson, O., Yaari, A., Margalith, M.
Format: Article
Language:English
Subjects:
academic stress
Adult
Antibodies, Viral - analysis
Biological and medical sciences
Enzyme-Linked Immunosorbent Assay
Epstein-Barr virus
Epstein-Barr Virus Infections - etiology
Epstein-Barr Virus Infections - immunology
Female
health status
hepatitis A virus
Herpesvirus 4, Human - immunology
Human viral diseases
Humans
IgG and IgA salivary antibodies
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Infectious diseases
Medical sciences
menstrual cycle
Menstrual Cycle - immunology
Saliva - immunology
Stress, Psychological - complications
Stress, Psychological - immunology
Stress, Psychological - virology
Students, Medical
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virus Activation
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Summary:Epstein‐Barr virus (EBV) is prevalent in 90% of the population. After primary infection it remains in a latent state and the majority of the virus carriers are asymptomatic during their life. Among the immunocompromized patients such as organ and bone marrow transplant recipients, individuals lacking T cell immunity, and patients treated with corticosteroid, cancer, and AIDS patients EBV primary infection and reactivation can cause life threatening diseases. Immunosupression may occur also during stressful events, which induce corticosteroid release and thus activate EBV. The effect of examination stress on EBV reactivation among female students was studied by detecting the values of EBV specific IgG and IgA salivary antibodies. Sequential saliva samples were obtained from first year female students before, during, and after two important examinations. EBV specific IgG and IgA salivary antibodies were tested by enzyme‐linked immunosorbent assay (ELISA). Hepatitis A virus (HAV) salivary antibodies served as a non‐latent virus control. A statistically significant increase in the values of EBV specific IgG and IgA antibodies was detected in samples collected during the examinations, as compared to the samples collected two months before and one month after the exams (P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.1030