Extraosseous Uptake of Tc-99m HDP in Muscular Dystrophy

A 43-year-old woman with muscular dystrophy was admitted for sudden onset of rhabdomyolysis and myoglobinuria. Serum creatine phosphokinase levels peaked at 230,000 U/l. Her family history was positive for muscle carnitine palmityl transferase deficiency, with episodic myoglobinuria in a sister. The...

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Bibliographic Details
Published in:Clinical nuclear medicine 2000-02, Vol.25 (2), p.135-135
Main Authors: NYE, PETER J, AELION, JACOB A, ODHAV, SATISH K, BAIN, SHONDRA
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Diseases of striated muscles. Neuromuscular diseases
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Muscle, Skeletal - diagnostic imaging
Muscular Dystrophies - diagnostic imaging
Neurology
Osteoarticular system. Muscles
Radionuclide Imaging
Radionuclide investigations
Radiopharmaceuticals
Rhabdomyolysis - diagnostic imaging
Technetium Tc 99m Medronate - analogs & derivatives
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Summary:A 43-year-old woman with muscular dystrophy was admitted for sudden onset of rhabdomyolysis and myoglobinuria. Serum creatine phosphokinase levels peaked at 230,000 U/l. Her family history was positive for muscle carnitine palmityl transferase deficiency, with episodic myoglobinuria in a sister. The results of a workup for toxic, infectious, and inflammatory myopathic causes were negative. A whole-body bone scan was performed. Treatment consisted of bed rest and fluids, with resolution of her symptoms and abnormal laboratory findings within 3 weeks. Bizarre extraosseous uptake with bone scintigraphy has been documented in cases of rhabdomyolysis caused by drugs and strenuous activity.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-200002000-00013