Do Quiescent Human Peripheral Lymphocytes Repair Radiation-Induced Chromosome Damage?

Kondrashova, T.V. and Ivanova, T.I. Do Quiescent Human Peripheral Lymphocytes Repair Radiation-Induced Chromosome Damage? Peripheral blood samples from seven healthy donors were exposed to 2 Gy of 60 Co γ rays. Lymphocyte cultures were prepared from the samples and stimulated to proliferate either i...

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Bibliographic Details
Published in:Radiation research 2000-01, Vol.153 (1), p.122-124
Main Authors: Kondrashova, Tatiana V., Ivanova, Tatiana I.
Format: Article
Language:English
Subjects:
Blood
Cells, Cultured
CHO cells
Chromosome Aberrations
Chromosomes
Chromosomes, Human - genetics
Chromosomes, Human - radiation effects
DNA Damage
DNA Repair - radiation effects
Fibroblasts
Gamma Rays
Humans
In Vitro Techniques
Irradiation
Lesions
Lymphocyte Activation
Lymphocytes
Lymphocytes - pathology
Lymphocytes - radiation effects
Radiation damage
SHORT COMMUNICATION
Space life sciences
Time Factors
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Summary:Kondrashova, T.V. and Ivanova, T.I. Do Quiescent Human Peripheral Lymphocytes Repair Radiation-Induced Chromosome Damage? Peripheral blood samples from seven healthy donors were exposed to 2 Gy of 60 Co γ rays. Lymphocyte cultures were prepared from the samples and stimulated to proliferate either immediately after the exposure or after 1, 2 or 4 h. No significant differences were found between the frequencies of chromosome aberrations (breaks or exchange) observed in lymphocytes stimulated after different postirradiation periods. We conclude that unstimulated lymphocytes do not undergo significant levels of recovery from potentially lethal damage at the chromosomal level.
ISSN:0033-7587
1938-5404
DOI:10.1667/0033-7587(2000)153[0122:DQHPLR]2.0.CO;2