Temporal age-related changes in spectral, fractal and complexity characteristics of heart rate variability

Cross‐sectional studies have suggested that heart rate (HR) variability, analysed using traditional time and frequency domain methods, is related to ageing, but no longitudinal studies have estimated the age dependence of HR fluctuation. This study evaluated temporal age‐related changes in 12‐h meas...

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Bibliographic Details
Published in:Clinical physiology (Oxford) 2001-05, Vol.21 (3), p.273-281
Main Authors: Jokinen, Vesa, Syvänne, Mikko, Mäkikallio, Timo H., Airaksinen, K. E. Juhani, Huikuri, Heikki V.
Format: Article
Language:English
Subjects:
Aged
Aging - physiology
Angiography
Biological and medical sciences
Cardiology. Vascular system
coronary artery disease
Coronary Disease - etiology
Coronary heart disease
Disease Progression
electrocardiography
Heart
Heart Rate - physiology
Humans
Longitudinal Studies
Male
Medical sciences
Middle Aged
Models, Theoretical
Risk Factors
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Summary:Cross‐sectional studies have suggested that heart rate (HR) variability, analysed using traditional time and frequency domain methods, is related to ageing, but no longitudinal studies have estimated the age dependence of HR fluctuation. This study evaluated temporal age‐related changes in 12‐h measures of HR variability among 109 patients with coronary artery disease (CAD), who underwent repeat Holter recordings at 32‐month intervals. Time and frequency domain measures, along with fractal and complexity measures of HR variability, were determined at the baseline and after 32 months. Changes in HR dynamics were compared with various laboratory variables, exercise data and angiographic progression of CAD. Traditional time and frequency domain measures of HR variability did not change significantly during the follow‐up, but the power‐law scaling slope decreased from −1·29 ± 0·20 to −1·36 ± 0·23 (P
ISSN:0144-5979
1365-2281
DOI:10.1046/j.1365-2281.2001.00326.x