Mineralocorticoid action

The physiology of mineralocorticoid action, particularly with respect to epithelial sodium transport, is well defined. A full understanding of the molecular basis of mineralocorticoid action has however proven to be more elusive. In the last decade insights into structural and functional aspects of...

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Bibliographic Details
Published in:Steroids 2000-02, Vol.65 (2), p.61-73
Main Authors: Rogerson, Fraser M, Fuller, Peter J
Format: Article
Language:English
Subjects:
Adrenals. Interrenals
Adrenomedullary hormones. Regulation
Aldosterone
Aldosterone - pharmacology
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Humans
Ion Transport - drug effects
Mineralocorticoids - pharmacology
Potassium - metabolism
Receptor
Receptors, Mineralocorticoid - chemistry
Receptors, Mineralocorticoid - genetics
Receptors, Mineralocorticoid - physiology
Sodium - metabolism
Sodium channel
Sodium transport
Vertebrates: endocrinology
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Summary:The physiology of mineralocorticoid action, particularly with respect to epithelial sodium transport, is well defined. A full understanding of the molecular basis of mineralocorticoid action has however proven to be more elusive. In the last decade insights into structural and functional aspects of the mineralocorticoid receptor combined with emerging details of the components of the mediators of the sodium flux has resulted in a clearer picture. This review focuses on two aspects of these new developments; the mineralocorticoid receptor and putative aldosterone induced proteins.
ISSN:0039-128X
1878-5867
DOI:10.1016/S0039-128X(99)00087-2