Molecular cytogenetic characterization of an acquired minute supernumerary marker chromosome as the sole abnormality in a case clinically diagnosed as atypical Philadelphia‐negative chronic myelogenous leukaemia

A case of chronic myelogenous leukaemia (CML) in a 48‐year‐old man is reported. To the best of our knowledge, this is the first report of a Philadelphia‐negative CML with an acquired small supernumerary marker chromosome (SMC) 11 as the sole abnormality. The derivative chromosome 11 was studied in d...

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Bibliographic Details
Published in:British journal of haematology 2001-05, Vol.113 (2), p.435-438
Main Authors: Starke, Heike, Raida, Martin, Trifonov, Vladimir, Clement, Joachim H., Loncarevic, Ivan F., Heller, Anita, Bleck, Cordula, Nietzel, Angela, Rubtsov, Nikolai, Claussen, Uwe, Liehr, Thomas
Format: Article
Language:English
Subjects:
Chromosome Aberrations - genetics
Chromosome Disorders
Chromosomes, Human, Pair 11
CML
FISH
Genetic Markers
Humans
Image Processing, Computer-Assisted
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative - genetics
Male
micro‐CGH
Middle Aged
multicolour banding (MCB)
Philadelphia negative
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Summary:A case of chronic myelogenous leukaemia (CML) in a 48‐year‐old man is reported. To the best of our knowledge, this is the first report of a Philadelphia‐negative CML with an acquired small supernumerary marker chromosome (SMC) 11 as the sole abnormality. The derivative chromosome 11 was studied in detail using molecular cytogenetic methods; fluorescence in situ hybridization (FISH) using centromere‐ and region‐specific probes for chromosome 11, microdissection, micro‐comparative genomic hybridization (micro‐CGH) and the recently developed multicolour banding (MCB) technique. The acquired SMC was determined to be a ring chromosome that can be described as r(11)(:p11.2→q13.1::q14:).
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2001.02787.x