Evaluation of CD14 in host defence

An extensive search for the cell membrane targets for lipopolysaccharide (LPS), the major causative agent of Gram‐negative septic shock, resulted in the identification of CD14 as the major endotoxin ‘receptor’. Besides recognition of LPS, several new aspects of its biological functions have been des...

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Bibliographic Details
Published in:European journal of clinical investigation 2000-02, Vol.30 (2), p.167-179
Main Author: Antal-Szalmás
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone Marrow Cells - immunology
CD14
Fundamental and applied biological sciences. Psychology
General aspects
Human infectious diseases. Experimental studies and models
Humans
Immunity, Innate
Infectious diseases
Inflammation
Lipopolysaccharide Receptors - metabolism
Lipopolysaccharides - metabolism
LPS
LPS-receptor
Medical sciences
Models, Biological
Molecular and cellular biology
sepsis
septic shock
Shock, Septic - immunology
Signal Transduction
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Summary:An extensive search for the cell membrane targets for lipopolysaccharide (LPS), the major causative agent of Gram‐negative septic shock, resulted in the identification of CD14 as the major endotoxin ‘receptor’. Besides recognition of LPS, several new aspects of its biological functions have been described recently. In this review the different CD14 forms, their most important biological and biochemical features, signalling properties, cellular and subcellular distribution and association with different diseases are discussed in detail, showing that these molecules posses several unique biological functions and further proving their central role in innate immunity.
ISSN:0014-2972
1365-2362
DOI:10.1046/j.1365-2362.2000.00610.x