Influence of oral dehydroepiandrosterone (DHEA) on urinary steroid metabolites in males and females

• Published in: Steroids 2000-02, Vol.65 (2), p.98-102
• Main Authors: Callies, Frank, Arlt, Wiebke, Siekmann, Lothar, Hübler, Doris, Bidlingmaier, Frank, Allolio, Bruno
• Format: Article
• Language: English
• Subjects: Administration, Oral; Adrenal insufficiency; Adult; Androgens - metabolism; Androgens - pharmacokinetics; Androgens - urine; Androsterone; Biological and medical sciences; Chromatography; Dehydroepiandrosterone (DHEA); Dehydroepiandrosterone - administration & dosage; Dehydroepiandrosterone - metabolism; Dexamethasone - pharmacology; Dose-Response Relationship, Drug; Etiocholanolone; Female; Hormones. Endocrine system; Humans; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Sex Factors; Tetrahydrocortisol - metabolism; Tetrahydrocortisol - urine; Tetrahydrocortisone - metabolism; Tetrahydrocortisone - urine; Urinary steroid excretion
• ISSN: 0039-128X; 1878-5867
• DOI: 10.1016/S0039-128X(99)00090-2

Oral dehydroepiandrosterone (DHEA) replacement therapy may have a multitude of potential beneficial effects and exerts its action mainly via peripheral bioconversion to androgens (and estrogens). A daily dose of 50-mg DHEA has been shown by us and others to restore low endogenous serum DHEA concentrations to normal youthful levels followed by an increase in circulating androgens and estrogens. As the hepatic first-pass effect may lead to a non physiological metabolism of DHEA after oral ingestion we studied the influence of two single DHEA doses (50 and 100 mg) on the excretion of steroid metabolites in 14 elderly males [age 58.8 ± 5.1 years (mean ± SEM)] with endogenous DHEAS levels