Gallstones in sickle cell disease: Observations from The Jamaican: Cohort Study

The prevalence, incidence, risk factors, clinical associations, and morbidity of gallstones were studied in 311 patients with homozygous sickle cell disease and 167 patients with sickle cell-hemoglobin C disease in a cohort study from birth. Gallstones developed in 96 patients with homozygous sickle...

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Bibliographic Details
Published in:The Journal of pediatrics 2000-01, Vol.136 (1), p.80-85
Main Authors: Walker, Thomas M, Hambleton, Ian R, Serjeant, Graham R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemia, Sickle Cell - epidemiology
Anemia, Sickle Cell - genetics
Anemia, Sickle Cell - mortality
Anemias. Hemoglobinopathies
Biological and medical sciences
Child
Cholecystectomy
Cholelithiasis - complications
Cholelithiasis - epidemiology
Cholelithiasis - surgery
Cohort Studies
Diseases of red blood cells
Female
Follow-Up Studies
Hematologic and hematopoietic diseases
Hemoglobin SC Disease - epidemiology
Hemoglobin SC Disease - mortality
Homozygote
Humans
Incidence
Jamaica - epidemiology
Male
Medical sciences
Population Surveillance
Prevalence
Risk Factors
Survival Rate
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Summary:The prevalence, incidence, risk factors, clinical associations, and morbidity of gallstones were studied in 311 patients with homozygous sickle cell disease and 167 patients with sickle cell-hemoglobin C disease in a cohort study from birth. Gallstones developed in 96 patients with homozygous sickle cell disease and 18 patients with sickle cell-hemoglobin C disease; specific symptoms necessitating cholecystect0my occurred in only 7 patients with homozygous sickle cell disease.
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(00)90054-4