clk‐1, mitochondria, and physiological rates

Mutations in the C. elegans maternal‐effect gene clk‐1 are highly pleiotropic, affecting the duration of diverse developmental and behavioral processes. They result in an average slowing of embryonic and post‐embryonic development, adult rhythmic behaviors, reproduction, and aging.(1) CLK‐1 is a hig...

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Bibliographic Details
Published in:BioEssays 2000-01, Vol.22 (1), p.48-56
Main Authors: Branicky, Robyn, Bénard, Claire, Hekimi, Siegfried
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biological Clocks
Caenorhabditis - genetics
Caenorhabditis - physiology
Caenorhabditis elegans
Caenorhabditis elegans Proteins
clk-1 gene
CLK-1 protein
Conserved Sequence
Helminth Proteins - chemistry
Helminth Proteins - genetics
Helminth Proteins - physiology
Humans
Mitochondria - physiology
Molecular Sequence Data
Rickettsia - genetics
Saccharomyces cerevisiae - genetics
Sequence Alignment
Sequence Homology, Amino Acid
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Summary:Mutations in the C. elegans maternal‐effect gene clk‐1 are highly pleiotropic, affecting the duration of diverse developmental and behavioral processes. They result in an average slowing of embryonic and post‐embryonic development, adult rhythmic behaviors, reproduction, and aging.(1) CLK‐1 is a highly conserved mitochondrial protein,(2,3) but even severe clk‐1 mutations affect mitochondrial respiration only slightly.(3) Here, we review the evidence supporting the regulatory role of clk‐1 in physiological timing. We also discuss possible models for the action of CLK‐1, in particular, one proposing that CLK‐1 is involved in the coordination of mitochondrial and nuclear function. BioEssays 22:48–56, 2000. ©2000 John Wiley & Sons, Inc.
ISSN:0265-9247
1521-1878
DOI:10.1002/(SICI)1521-1878(200001)22:1<48::AID-BIES9>3.0.CO;2-F