Fine-needle aspiration of cytomegalovirus sialadenitis in a patient with acquired immunodeficiency syndrome: Pitfalls of diff-quik staining

• Published in: Diagnostic cytopathology 2000-02, Vol.22 (2), p.101-103
• Main Authors: Santiago, Kerri, Rivera, Ada, Cabaniss, Derek, Dhurhar, Nina, Moroz, Krzysztof
• Format: Article
• Language: English
• Subjects: acquired immunodeficiency syndrome; AIDS-Related Opportunistic Infections - diagnosis; AIDS-Related Opportunistic Infections - virology; AIDS/HIV; Biological and medical sciences; Biopsy, Needle; Cell Nucleus - pathology; Cell Nucleus - virology; cytomegalovirus; Cytomegalovirus Infections - diagnosis; Diagnosis, Differential; Diagnostic Errors; Histoplasmosis - diagnosis; Human viral diseases; Humans; Immunocompromised Host; Inclusion Bodies, Viral - pathology; Infectious diseases; Male; Medical sciences; Middle Aged; Parotid Gland - pathology; Parotid Gland - virology; salivary gland; sialadenitis; Sialadenitis - diagnosis; Sialadenitis - virology; Staining and Labeling - methods; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids
• ISSN: 8755-1039; 1097-0339
• DOI: 10.1002/(SICI)1097-0339(200002)22:2<101::AID-DC8>3.0.CO;2-G

A case of cytomegalovirus (CMV) sialadenitis in a patient with acquired immunodeficiency syndrome (AIDS) diagnosed by fine‐needle aspiration biopsy (FNAB) is reported. Although a diagnosis of CMV sialadenitis can be established on Diff‐Quik‐stained slides, the characteristic viral changes are the best appreciated on slides stained by the Papanicolaou (Pap) technique. Differential pitfalls are discussed. It needs to be stressed that clinically unsuspected diagnosis of CMV infection may uncover congenital or acquired defects of cellular immunity, and particularly AIDS. Diagn. Cytopathol. 2000;22:101–103. © 2000 Wiley‐Liss, Inc.