A randomised phase II study on neo-adjuvant chemotherapy for ‘high-risk’ adult soft-tissue sarcoma

The aim of this study was to examine the strategy, feasibility and outcome of neo-adjuvant chemotherapy, with doxorubicin and ifosfamide, in adult patients with ‘high-risk’ soft-tissue sarcomas. Patients with ‘high-risk’ soft-tissue sarcomas, defined as tumours ⩾8 cm of any grade, or grade II/III tu...

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Bibliographic Details
Published in:European journal of cancer (1990) 2001-06, Vol.37 (9), p.1096-1103
Main Authors: Gortzak, E, Azzarelli, A, Buesa, J, Bramwell, V.H.C, van Coevorden, F, van Geel, A.N, Ezzat, A, Santoro, A, Oosterhuis, J.W, van Glabbeke, M, Kirkpatrick, A, Verweij, J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antineoplastic agents
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Chemotherapy
Chemotherapy, Adjuvant
Combined Modality Therapy - methods
Disease Progression
Disease-Free Survival
Doxorubicin - administration & dosage
Follow-Up Studies
Humans
Ifosfamide - administration & dosage
Medical sciences
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoadjuvant chemotherapy
Neoplasm Recurrence, Local - drug therapy
Neoplasm Recurrence, Local - surgery
Pharmacology. Drug treatments
Preoperative Care - methods
Randomised study
Risk Factors
Sarcoma - drug therapy
Sarcoma - radiotherapy
Sarcoma - surgery
Soft-tissue sarcoma
Tumors
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Description
Summary:The aim of this study was to examine the strategy, feasibility and outcome of neo-adjuvant chemotherapy, with doxorubicin and ifosfamide, in adult patients with ‘high-risk’ soft-tissue sarcomas. Patients with ‘high-risk’ soft-tissue sarcomas, defined as tumours ⩾8 cm of any grade, or grade II/III tumours
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(01)00083-1