Magnetoencephalographic analysis of periodic lateralized epileptiform discharges (PLEDs)

To clarify the spatial and temporal distribution of the electroencephalographic (EEG) pattern termed 'periodic lateralized epileptiform discharges' (PLEDs), we performed magnetoencephalography (MEG) to analyze PLEDs in a patient with a right parietal metastasis associated with meningeal ca...

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Bibliographic Details
Published in:Clinical neurophysiology 2000, Vol.111 (1), p.122-127
Main Authors: HISADA, K, MORIOKA, T, NISHIO, S, MURAISHI, M, YAMAMOTO, T, YOSHIDA, T, FUKUI, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain Mapping
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - pathology
Cerebral Cortex - physiopathology
Electrodiagnosis. Electric activity recording
Epilepsy - diagnostic imaging
Epilepsy - pathology
Epilepsy - physiopathology
Functional Laterality
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Magnetoencephalography - methods
Male
Medical sciences
Middle Aged
Nervous system
Parietal Lobe - diagnostic imaging
Parietal Lobe - pathology
Radiopharmaceuticals
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon
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Summary:To clarify the spatial and temporal distribution of the electroencephalographic (EEG) pattern termed 'periodic lateralized epileptiform discharges' (PLEDs), we performed magnetoencephalography (MEG) to analyze PLEDs in a patient with a right parietal metastasis associated with meningeal carcinomatosis. A 37-channel biomagnetometer was used to simultaneously record the EEG and MEG. Equivalent current dipole (ECD) source localization was calculated based on a single-dipole model and mapped onto a magnetic resonance image. Single-photon emission computed tomography with technetium-99-hexamethyl-propyleneamine oxime (HMPAO-SPECT study) was also performed during both presence and absence of PLEDs according to an EEG monitor. By EEG the PLEDs, predominantly right-sided, consisted of a typical negative triphasic spike followed by a slow negative wave. By MEG the PLEDs had a sequence with 3 distinct components. ECDs in the 3 components were localized to the cortex around the lesion, although exact localization and dipole direction varied between components. HMPAO-SPECT demonstrated hypoperfusion of the lesion and adjacent cortex during both quiescence and appearance of PLEDs. Our results indicate that PLEDs originated from the hypoperfused cortex surrounding the lesion.
ISSN:1388-2457
1872-8952
DOI:10.1016/s1388-2457(99)00184-4