No evidence for linkage by transmission disequilibrium test analysis of microsatellite marker D22S278 and schizophrenia in a Palestinian Arab and in a German population

Linkage for a schizophrenia susceptibility locus on chromosome region 22q12–q13 was initially suggested by independent studies from two groups and confirmed in a combined analysis of data for the microsatellite marker D22S278 in multiply affected schizophrenic families derived from 11 independent re...

Full description

Saved in:
Bibliographic Details
Published in:American journal of medical genetics 2001-05, Vol.105 (4), p.328-331
Main Authors: Dobrusin, M., Corbex, Marilys, Kremer, I., Murad, I., Muhaheed, M., Bannoura, I., Müller, D.J., Schulze, T.G., Reshef, A., Blanaru, M., Gathas, S., Rietschel, M., Belmaker, R.H., Maier, W., Ebstein, Richard P.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Alleles
Arabs - genetics
Biological and medical sciences
chromosome 22
Chromosomes, Human, Pair 22 - genetics
D22S278
DNA - genetics
Gene Frequency
genetics
Genotype
Germany
Humans
Israel - ethnology
linkage
Linkage Disequilibrium
Medical genetics
Medical sciences
Mental and behavioral disorders
Microsatellite Repeats
polymorphism
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - genetics
transmission disequilibrium test
Tropical medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Linkage for a schizophrenia susceptibility locus on chromosome region 22q12–q13 was initially suggested by independent studies from two groups and confirmed in a combined analysis of data for the microsatellite marker D22S278 in multiply affected schizophrenic families derived from 11 independent research groups worldwide. In addition to these reports of linkage to schizophrenia on chromosome 22, bipolar disorder has also been linked to markers in this chromosomal region. We now report results from an analysis of 223 Palestinian Arab trios from three different centers in Israel and Palestine using the allele‐wise extended transmission disequilibrium test for multiallelic markers. No evidence for linkage is observed in the entire group or in any of the three centers (entire group: chi‐square = 5.59, P = 0.78, df = 9; Afula: chi‐square = 6.51, P = 0.48, df = 7; Bethlehem: chi‐square = 14.11, P = 0.12, df = 9; Beersheva: chi‐square = 7.04, P = 0.32, df = 6). Additionally, we examined D22S278 in a group of 114 schizophrenic German triads and failed to observe evidence for linkage (chi‐square = 8.13, P = 0.42, df = 8df). © 2001 Wiley‐Liss, Inc.
ISSN:0148-7299
1096-8628
DOI:10.1002/ajmg.1345