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No evidence for linkage by transmission disequilibrium test analysis of microsatellite marker D22S278 and schizophrenia in a Palestinian Arab and in a German population
Linkage for a schizophrenia susceptibility locus on chromosome region 22q12–q13 was initially suggested by independent studies from two groups and confirmed in a combined analysis of data for the microsatellite marker D22S278 in multiply affected schizophrenic families derived from 11 independent re...
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| Published in: | American journal of medical genetics 2001-05, Vol.105 (4), p.328-331 |
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| Main Authors: | , , , , , , , , , , , , , , |
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| container_end_page | 331 |
| container_issue | 4 |
| container_start_page | 328 |
| container_title | American journal of medical genetics |
| container_volume | 105 |
| creator | Dobrusin, M. Corbex, Marilys Kremer, I. Murad, I. Muhaheed, M. Bannoura, I. Müller, D.J. Schulze, T.G. Reshef, A. Blanaru, M. Gathas, S. Rietschel, M. Belmaker, R.H. Maier, W. Ebstein, Richard P. |
| description | Linkage for a schizophrenia susceptibility locus on chromosome region 22q12–q13 was initially suggested by independent studies from two groups and confirmed in a combined analysis of data for the microsatellite marker D22S278 in multiply affected schizophrenic families derived from 11 independent research groups worldwide. In addition to these reports of linkage to schizophrenia on chromosome 22, bipolar disorder has also been linked to markers in this chromosomal region. We now report results from an analysis of 223 Palestinian Arab trios from three different centers in Israel and Palestine using the allele‐wise extended transmission disequilibrium test for multiallelic markers. No evidence for linkage is observed in the entire group or in any of the three centers (entire group: chi‐square = 5.59, P = 0.78, df = 9; Afula: chi‐square = 6.51, P = 0.48, df = 7; Bethlehem: chi‐square = 14.11, P = 0.12, df = 9; Beersheva: chi‐square = 7.04, P = 0.32, df = 6). Additionally, we examined D22S278 in a group of 114 schizophrenic German triads and failed to observe evidence for linkage (chi‐square = 8.13, P = 0.42, df = 8df). © 2001 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajmg.1345 |
| format | article |
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In addition to these reports of linkage to schizophrenia on chromosome 22, bipolar disorder has also been linked to markers in this chromosomal region. We now report results from an analysis of 223 Palestinian Arab trios from three different centers in Israel and Palestine using the allele‐wise extended transmission disequilibrium test for multiallelic markers. No evidence for linkage is observed in the entire group or in any of the three centers (entire group: chi‐square = 5.59, P = 0.78, df = 9; Afula: chi‐square = 6.51, P = 0.48, df = 7; Bethlehem: chi‐square = 14.11, P = 0.12, df = 9; Beersheva: chi‐square = 7.04, P = 0.32, df = 6). Additionally, we examined D22S278 in a group of 114 schizophrenic German triads and failed to observe evidence for linkage (chi‐square = 8.13, P = 0.42, df = 8df). © 2001 Wiley‐Liss, Inc.</description><identifier>ISSN: 0148-7299</identifier><identifier>EISSN: 1096-8628</identifier><identifier>DOI: 10.1002/ajmg.1345</identifier><identifier>PMID: 11378845</identifier><identifier>CODEN: AJMGDA</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult and adolescent clinical studies ; Alleles ; Arabs - genetics ; Biological and medical sciences ; chromosome 22 ; Chromosomes, Human, Pair 22 - genetics ; D22S278 ; DNA - genetics ; Gene Frequency ; genetics ; Genotype ; Germany ; Humans ; Israel - ethnology ; linkage ; Linkage Disequilibrium ; Medical genetics ; Medical sciences ; Mental and behavioral disorders ; Microsatellite Repeats ; polymorphism ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - genetics ; transmission disequilibrium test ; Tropical medicine</subject><ispartof>American journal of medical genetics, 2001-05, Vol.105 (4), p.328-331</ispartof><rights>Copyright © 2001 Wiley‐Liss, Inc.</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3885-1729c94038961594f68717e439b03c173b2d68b812fb8fa7d5b354ade88ada623</citedby><cites>FETCH-LOGICAL-c3885-1729c94038961594f68717e439b03c173b2d68b812fb8fa7d5b354ade88ada623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1031966$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11378845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dobrusin, M.</creatorcontrib><creatorcontrib>Corbex, Marilys</creatorcontrib><creatorcontrib>Kremer, I.</creatorcontrib><creatorcontrib>Murad, I.</creatorcontrib><creatorcontrib>Muhaheed, M.</creatorcontrib><creatorcontrib>Bannoura, I.</creatorcontrib><creatorcontrib>Müller, D.J.</creatorcontrib><creatorcontrib>Schulze, T.G.</creatorcontrib><creatorcontrib>Reshef, A.</creatorcontrib><creatorcontrib>Blanaru, M.</creatorcontrib><creatorcontrib>Gathas, S.</creatorcontrib><creatorcontrib>Rietschel, M.</creatorcontrib><creatorcontrib>Belmaker, R.H.</creatorcontrib><creatorcontrib>Maier, W.</creatorcontrib><creatorcontrib>Ebstein, Richard P.</creatorcontrib><title>No evidence for linkage by transmission disequilibrium test analysis of microsatellite marker D22S278 and schizophrenia in a Palestinian Arab and in a German population</title><title>American journal of medical genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>Linkage for a schizophrenia susceptibility locus on chromosome region 22q12–q13 was initially suggested by independent studies from two groups and confirmed in a combined analysis of data for the microsatellite marker D22S278 in multiply affected schizophrenic families derived from 11 independent research groups worldwide. In addition to these reports of linkage to schizophrenia on chromosome 22, bipolar disorder has also been linked to markers in this chromosomal region. We now report results from an analysis of 223 Palestinian Arab trios from three different centers in Israel and Palestine using the allele‐wise extended transmission disequilibrium test for multiallelic markers. No evidence for linkage is observed in the entire group or in any of the three centers (entire group: chi‐square = 5.59, P = 0.78, df = 9; Afula: chi‐square = 6.51, P = 0.48, df = 7; Bethlehem: chi‐square = 14.11, P = 0.12, df = 9; Beersheva: chi‐square = 7.04, P = 0.32, df = 6). Additionally, we examined D22S278 in a group of 114 schizophrenic German triads and failed to observe evidence for linkage (chi‐square = 8.13, P = 0.42, df = 8df). © 2001 Wiley‐Liss, Inc.</description><subject>Adult and adolescent clinical studies</subject><subject>Alleles</subject><subject>Arabs - genetics</subject><subject>Biological and medical sciences</subject><subject>chromosome 22</subject><subject>Chromosomes, Human, Pair 22 - genetics</subject><subject>D22S278</subject><subject>DNA - genetics</subject><subject>Gene Frequency</subject><subject>genetics</subject><subject>Genotype</subject><subject>Germany</subject><subject>Humans</subject><subject>Israel - ethnology</subject><subject>linkage</subject><subject>Linkage Disequilibrium</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Mental and behavioral disorders</subject><subject>Microsatellite Repeats</subject><subject>polymorphism</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - genetics</subject><subject>transmission disequilibrium test</subject><subject>Tropical medicine</subject><issn>0148-7299</issn><issn>1096-8628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u1DAUhS1ERYfCghdAXiAkFmn9k8TOclToFNoOSAV1ad0kTntb56d2AkyfiMfE04mADSvL9nfPveceQl5xdsgZE0dw214fcplmT8iCsyJPdC70U7JgPNWJEkWxT56HcMsYjw_iGdnnXCqt02xBfq17ar9jbbvK0qb31GF3B9eWlhs6euhCiyFg39Eag72f0GHpcWrpaMNIoQO3CRho39AWK98HGK1zOFragr-znr4X4lIoHcmahuoGH_rhxtsOgWJHgX4BF3Uw3ju69FA-co8_K-vb-Dj0w-RgjAO8IHsNuGBfzucB-Xby4evxaXL-efXxeHmeVFLrLOHRblWkTOoi51mRNrlWXNlUFiWTFVeyFHWuS81FU-oGVJ2VMkuhtlpDDbmQB-TtTnfw_f0UpzNxA1V0BZ3tp2AU05qlTEXw3Q7c-g7eNmbwGG1vDGdmG4vZxmK2sUT29Sw6la2t_5JzDhF4MwMQKnBN3HyF4R9FyYs8j9jRDvuBzm7-39AsP12s5s7JrgLDaH_-qYjpmFxJlZmr9cqsT84u5QW7Mlr-BhWPtSM</recordid><startdate>20010508</startdate><enddate>20010508</enddate><creator>Dobrusin, M.</creator><creator>Corbex, Marilys</creator><creator>Kremer, I.</creator><creator>Murad, I.</creator><creator>Muhaheed, M.</creator><creator>Bannoura, I.</creator><creator>Müller, D.J.</creator><creator>Schulze, T.G.</creator><creator>Reshef, A.</creator><creator>Blanaru, M.</creator><creator>Gathas, S.</creator><creator>Rietschel, M.</creator><creator>Belmaker, R.H.</creator><creator>Maier, W.</creator><creator>Ebstein, Richard P.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010508</creationdate><title>No evidence for linkage by transmission disequilibrium test analysis of microsatellite marker D22S278 and schizophrenia in a Palestinian Arab and in a German population</title><author>Dobrusin, M. ; Corbex, Marilys ; Kremer, I. ; Murad, I. ; Muhaheed, M. ; Bannoura, I. ; Müller, D.J. ; Schulze, T.G. ; Reshef, A. ; Blanaru, M. ; Gathas, S. ; Rietschel, M. ; Belmaker, R.H. ; Maier, W. ; Ebstein, Richard P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3885-1729c94038961594f68717e439b03c173b2d68b812fb8fa7d5b354ade88ada623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Alleles</topic><topic>Arabs - genetics</topic><topic>Biological and medical sciences</topic><topic>chromosome 22</topic><topic>Chromosomes, Human, Pair 22 - genetics</topic><topic>D22S278</topic><topic>DNA - genetics</topic><topic>Gene Frequency</topic><topic>genetics</topic><topic>Genotype</topic><topic>Germany</topic><topic>Humans</topic><topic>Israel - ethnology</topic><topic>linkage</topic><topic>Linkage Disequilibrium</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Mental and behavioral disorders</topic><topic>Microsatellite Repeats</topic><topic>polymorphism</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - genetics</topic><topic>transmission disequilibrium test</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dobrusin, M.</creatorcontrib><creatorcontrib>Corbex, Marilys</creatorcontrib><creatorcontrib>Kremer, I.</creatorcontrib><creatorcontrib>Murad, I.</creatorcontrib><creatorcontrib>Muhaheed, M.</creatorcontrib><creatorcontrib>Bannoura, I.</creatorcontrib><creatorcontrib>Müller, D.J.</creatorcontrib><creatorcontrib>Schulze, T.G.</creatorcontrib><creatorcontrib>Reshef, A.</creatorcontrib><creatorcontrib>Blanaru, M.</creatorcontrib><creatorcontrib>Gathas, S.</creatorcontrib><creatorcontrib>Rietschel, M.</creatorcontrib><creatorcontrib>Belmaker, R.H.</creatorcontrib><creatorcontrib>Maier, W.</creatorcontrib><creatorcontrib>Ebstein, Richard P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of medical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dobrusin, M.</au><au>Corbex, Marilys</au><au>Kremer, I.</au><au>Murad, I.</au><au>Muhaheed, M.</au><au>Bannoura, I.</au><au>Müller, D.J.</au><au>Schulze, T.G.</au><au>Reshef, A.</au><au>Blanaru, M.</au><au>Gathas, S.</au><au>Rietschel, M.</au><au>Belmaker, R.H.</au><au>Maier, W.</au><au>Ebstein, Richard P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No evidence for linkage by transmission disequilibrium test analysis of microsatellite marker D22S278 and schizophrenia in a Palestinian Arab and in a German population</atitle><jtitle>American journal of medical genetics</jtitle><addtitle>Am. J. Med. Genet</addtitle><date>2001-05-08</date><risdate>2001</risdate><volume>105</volume><issue>4</issue><spage>328</spage><epage>331</epage><pages>328-331</pages><issn>0148-7299</issn><eissn>1096-8628</eissn><coden>AJMGDA</coden><abstract>Linkage for a schizophrenia susceptibility locus on chromosome region 22q12–q13 was initially suggested by independent studies from two groups and confirmed in a combined analysis of data for the microsatellite marker D22S278 in multiply affected schizophrenic families derived from 11 independent research groups worldwide. In addition to these reports of linkage to schizophrenia on chromosome 22, bipolar disorder has also been linked to markers in this chromosomal region. We now report results from an analysis of 223 Palestinian Arab trios from three different centers in Israel and Palestine using the allele‐wise extended transmission disequilibrium test for multiallelic markers. No evidence for linkage is observed in the entire group or in any of the three centers (entire group: chi‐square = 5.59, P = 0.78, df = 9; Afula: chi‐square = 6.51, P = 0.48, df = 7; Bethlehem: chi‐square = 14.11, P = 0.12, df = 9; Beersheva: chi‐square = 7.04, P = 0.32, df = 6). Additionally, we examined D22S278 in a group of 114 schizophrenic German triads and failed to observe evidence for linkage (chi‐square = 8.13, P = 0.42, df = 8df). © 2001 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11378845</pmid><doi>10.1002/ajmg.1345</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Alleles Arabs - genetics Biological and medical sciences chromosome 22 Chromosomes, Human, Pair 22 - genetics D22S278 DNA - genetics Gene Frequency genetics Genotype Germany Humans Israel - ethnology linkage Linkage Disequilibrium Medical genetics Medical sciences Mental and behavioral disorders Microsatellite Repeats polymorphism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - genetics transmission disequilibrium test Tropical medicine |
| title | No evidence for linkage by transmission disequilibrium test analysis of microsatellite marker D22S278 and schizophrenia in a Palestinian Arab and in a German population |
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