bcl‐2 expression in non‐Hodgkin's lymphomas is not associated with bcl‐2 gene rearrangements

Previous reports have associated bcl‐2 gene rearrangements found in non‐Hodgkin's lymphomas with an inappropriately elevated bcl‐2 expression compared with the mature B‐cell stage of development. This study investigates bcl‐2 expression in non‐Hodgkin's lymphomas (NHL) without bcl‐2 gene r...

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Bibliographic Details
Published in:British journal of haematology 2001-05, Vol.113 (2), p.383-390
Main Authors: Papakonstantinou, Georgios, Verbeke, Caroline, Hastka, Jan, Bohrer, Manfred, Hehlmann, Rüdiger
Format: Article
Language:English
Subjects:
Autoradiography
bcl‐2
Biological and medical sciences
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
expression
Gene Expression
Gene Rearrangement
Genes, bcl-2
Hematologic and hematopoietic diseases
Hematology
Humans
Immunohistochemistry
In Situ Hybridization
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Non-Hodgkin - genetics
Medical sciences
non‐Hodgkin lymphoma
Proto-Oncogene Proteins c-bcl-2 - analysis
rearrangement
t(14
18) translocation
Translocation, Genetic
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Summary:Previous reports have associated bcl‐2 gene rearrangements found in non‐Hodgkin's lymphomas with an inappropriately elevated bcl‐2 expression compared with the mature B‐cell stage of development. This study investigates bcl‐2 expression in non‐Hodgkin's lymphomas (NHL) without bcl‐2 gene rearrangements. Molecular analysis in 168 patients with NHL revealed 45 patients without bcl‐2 gene rearrangements in which additional immunostaining for bcl‐2 protein was possible. An unexpectedly high prevalence (39/45) of bcl‐2 expression was found. The levels and patterns of bcl‐2 expression were not specific for the histological type of NHL and were similar to those shown in comparable cases with bcl‐2 gene rearrangements. In conclusion, bcl‐2 expression is not specific for NHL bearing bcl‐2 gene rearrangements. This finding implicates the existence of other deregulating control mechanisms of bcl‐2 expression, more important than bcl‐2 gene rearrangements.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2001.02727.x