Association of low plasma cholesterol with mortality for cancer at various sites in men : 17-y follow-up of the prospective Basel study

Low serum cholesterol has been associated with an increased risk of cancer mortality in various studies, which has led to uncertainty regarding the benefit of lower blood cholesterol. The aim of our study was to evaluate the association between low blood cholesterol (60 y of age with low plasma chol...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2000-02, Vol.71 (2), p.569-574
Main Authors: EICHHOLZER, M, STÄHELIN, H. B, GUTZWILLER, F, LÜDIN, E, BERNASCONI, F
Format: Article
Language:English
Subjects:
Age Factors
Antioxidants
Ascorbic Acid - blood
Biological and medical sciences
Cancer
Cholesterol
Cholesterol - blood
Cohort Studies
Colonic Neoplasms - mortality
Epidemiology
Follow-Up Studies
Humans
Lung Neoplasms - mortality
Male
Medical sciences
Middle Aged
Neoplasms - blood
Neoplasms - mortality
Neoplasms - pathology
Prospective Studies
Prostatic Neoplasms - mortality
Risk Factors
Smoking
Stomach Neoplasms - mortality
Switzerland
Tumors
Vitamin A - blood
Vitamin E - blood
Vitamins
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Summary:Low serum cholesterol has been associated with an increased risk of cancer mortality in various studies, which has led to uncertainty regarding the benefit of lower blood cholesterol. The aim of our study was to evaluate the association between low blood cholesterol (60 y of age with low plasma cholesterol. When data from the first 2 y of follow-up were excluded from the analysis, the relative risk estimates remained practically unchanged with regard to lung cancer but decreased for colon, prostate, and overall cancer. Increased cancer mortality risks associated with low plasma cholesterol were not explained by the confounding effect of antioxidant vitamins, but were attributed in part to the effect of preexisting cancer.
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/71.2.569