Morphogenetic tissue movement and the establishment of body plan during development from blastocyst to gastrula in the mouse

In many animal species, the early development of the embryo follows a stereotypic pattern of cell cleavage, lineage allocation and generation of tissue asymmetry leading to delineation of the body plan with three primary embryonic axes. The mammalian embryo has been regarded as an exception and prim...

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Bibliographic Details
Published in:BioEssays 2001-06, Vol.23 (6), p.508-517
Main Authors: Tam, Patrick P. L., Gad, Jacqueline M., Kinder, Simon J., Tsang, Tania E., Behringer, Richard R.
Format: Article
Language:English
Subjects:
Animals
Blastocyst - cytology
Blastocyst - physiology
Body Patterning
Endoderm - cytology
Endoderm - physiology
Gastrula - cytology
Gastrula - physiology
Mice - embryology
Morphogenesis
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Summary:In many animal species, the early development of the embryo follows a stereotypic pattern of cell cleavage, lineage allocation and generation of tissue asymmetry leading to delineation of the body plan with three primary embryonic axes. The mammalian embryo has been regarded as an exception and primary body axes of the mouse embryo were thought to develop after implantation. However, recent findings have challenged this view. Asymmetry in the fertilised oocyte, as defined by the position of the second polar body and the sperm entry point, can be correlated with the orientation of the animal–vegetal and the embryonic–abembryonic axes in the preimplantation blastocyst. Studies of the pattern of morphogenetic movement of cells and genetic activity in the peri‐implantation embryo suggest that the animal–vegetal axis of the blastocyst might presage the orientation of the anterior–posterior axis of the gastrula. This suggests that the asymmetry of the zygote that is established at fertilisation and early cleavage has a lasting impact on the delineation of body axes during embryogenesis. BioEssays 23:508–517, 2001. © 2001 John Wiley & Sons, Inc.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.1070