Post-antibiotic growth suppression of linezolid against Gram-positive bacteria

The in vitro post-antibiotic effects (PAEs) of eight different concentrations of linezolid against Gram-positive cocci were investigated and the results analysed using the sigmoid Emax model for mathematically modelling the PAE. Mean maximal linezolid PAEs against strains of Staphylococcus aureus, S...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2001-06, Vol.47 (6), p.879-883
Main Authors: Munckhof, W. J., Giles, C., Turnidge, J. D.
Format: Article
Language:English
Subjects:
Acetamides - pharmacology
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cell Division - drug effects
Enterococcus faecalis - drug effects
Enterococcus faecium - drug effects
Gram-Positive Bacteria - drug effects
Gram-Positive Bacteria - growth & development
Humans
Linezolid
Medical sciences
Microbial Sensitivity Tests
Oxazolidinones - pharmacology
Pharmacology. Drug treatments
Staphylococcus aureus - drug effects
Staphylococcus epidermidis - drug effects
Streptococcus pneumoniae - drug effects
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The in vitro post-antibiotic effects (PAEs) of eight different concentrations of linezolid against Gram-positive cocci were investigated and the results analysed using the sigmoid Emax model for mathematically modelling the PAE. Mean maximal linezolid PAEs against strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Enterococcus faecium and Streptococcus pneumoniae were 2.2, 1.8, 2.8, 2.0 and 3.0 h, respectively. Resistance to methicillin (for the staphylococci), vancomycin (for the enterococci) and penicillin (for the pneumococci) had no effect on the duration of the PAE. Results of PAE testing support twice-daily dosing of linezolid in humans.
ISSN:0305-7453
1460-2091
1460-2091
DOI:10.1093/jac/47.6.879