Abnormal myocardial mechanics in Kawasaki disease: Rapid response to γ-globulin

Background The time course and rate of recovery of myocardial dysfunction in association with Kawasaki disease in response to intravenous γ-globulin is unknown and may provide mechanistic clues. Methods and Results The acute changes in myocardial contractility in 25 patients with Kawasaki disease we...

Full description

Saved in:
Bibliographic Details
Published in:The American heart journal 2000-02, Vol.139 (2), p.217-223
Main Authors: Moran, Adrian M, Newburger, Jane W, Sanders, Stephen P, Parness, Ira A, Spevak, Philip J, Burns, Jane C, Colan, Steven D
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child, Preschool
Female
Humans
Immunoglobulins, Intravenous - therapeutic use
Infant
Male
Medical sciences
Mucocutaneous Lymph Node Syndrome - physiopathology
Myocardial Contraction - drug effects
Prospective Studies
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Treatment Outcome
Ventricular Dysfunction, Left - drug therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The time course and rate of recovery of myocardial dysfunction in association with Kawasaki disease in response to intravenous γ-globulin is unknown and may provide mechanistic clues. Methods and Results The acute changes in myocardial contractility in 25 patients with Kawasaki disease were evaluated by noninvasive stress-shortening and stress-velocity analysis. Echocardiograms were performed before and then daily for 4 days during which the patients received γ-globulin 1.6 to 2 g/kg. Before treatment, contractility was abnormally low
ISSN:0002-8703
1097-6744
DOI:10.1016/S0002-8703(00)90229-1