Bolus somatostatin but not octreotide reduces hepatic sinusoidal pressure by a NO‐independent mechanism in chronic liver disease

Background: Evidence exists that somatostatin and octreotide might have different effects on hepatic haemodynamics. Aim: The investigation of the effects of somatostatin and its octapeptide analogue, octreotide, on sinusoidal pressure measured by the wedged hepatic venous pressure in patients with c...

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Published in:Alimentary pharmacology & therapeutics 2001-06, Vol.15 (6), p.857-864
Main Authors: Matrella, E., Valatas, V., Notas, G., Roumpaki, H., Xidakis, C., Hadzidakis, A., Mouzas, I., Kouroumalis, E.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Digestive system
Female
Hemodynamics
Hemostatics - administration & dosage
Hemostatics - pharmacology
Hepatic Veins
Hepatitis, Chronic
Hormones - administration & dosage
Hormones - pharmacology
Humans
Injections, Intravenous
Liver - blood supply
Liver - drug effects
Liver Cirrhosis
Male
Medical sciences
Middle Aged
Octreotide - administration & dosage
Octreotide - pharmacology
Pharmacology. Drug treatments
Somatostatin - administration & dosage
Somatostatin - pharmacology
Venous Pressure - drug effects
Venous Pressure - physiology
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Summary:Background: Evidence exists that somatostatin and octreotide might have different effects on hepatic haemodynamics. Aim: The investigation of the effects of somatostatin and its octapeptide analogue, octreotide, on sinusoidal pressure measured by the wedged hepatic venous pressure in patients with cirrhosis or chronic hepatitis and the correlation with the levels of hepatic vein NO. Methods: Patients were randomly assigned to receive an injection of either 250 μg somatostatin (n=14: cirrhosis six, chronic hepatitis eight) or an injection of 125 μg octreotide (n=19: cirrhosis nine, chronic hepatitis 10) during hepatic vein catheterization. Baseline wedged hepatic venous pressure was measured, followed by measurements at 2, 5, 10 and 15 min after the injection of the drug. Nitrites/nitrates of the hepatic vein were measured before the injection and after 15 min. Results: Both agents showed a similar qualitative but a different quantitative haemodynamic profile. No change in the wedged hepatic venous pressure was observed during the first 2 min after the injection of both drugs. This was followed by a decrease: 18% at 5 min (N.S.), 23% at 10 min (P 
ISSN:0269-2813
1365-2036
DOI:10.1046/j.1365-2036.2001.00996.x