An Autocrine/Paracrine Mechanism Triggered by Myocardial Stretch Induces Changes in Contractility

Horacio E. Cingolani , Néstor G. Pérez and María C. Camilión de Hurtado H. E. Cingolani, N. G. Pérez, and M. C. Camilión de Hurtado are at the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina. An autocrine/paracrine...

Full description

Saved in:
Bibliographic Details
Published in:News in physiological sciences 2001-04, Vol.16 (2), p.88-91
Main Authors: Cingolani, Horacio E, Perez, Nestor G, Camilion de Hurtado, Maria C
Format: Article
Language:English
Subjects:
Animals
Autocrine Communication - physiology
Myocardial Contraction - physiology
Myocardium - metabolism
Paracrine Communication - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Horacio E. Cingolani , Néstor G. Pérez and María C. Camilión de Hurtado H. E. Cingolani, N. G. Pérez, and M. C. Camilión de Hurtado are at the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina. An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves release of angiotensin II, release/increased formation of endothelin, activation of the Na + /H + exchanger, increase in intracellular Na + , and the increase in the Ca 2+ transient that underlies the slow force response to stretch. The autocrine/paracrine mechanism could explain how changes in afterload alter cardiac contractility.
ISSN:1548-9213
0886-1714
1548-9221
DOI:10.1152/physiologyonline.2001.16.2.88