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Antibodies to factor XII and recurrent fetal loss in patients with the anti‐phospholipid syndrome
Forty female patients with either primary anti‐phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti‐phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2‐glycoprotein I and factor...
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| Published in: | British journal of haematology 2001-05, Vol.113 (2), p.550-552 |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4446-4466543a1a053f8288bfaf17f6336ab73092813cae53146c95e3507c143dad923 |
| container_end_page | 552 |
| container_issue | 2 |
| container_start_page | 550 |
| container_title | British journal of haematology |
| container_volume | 113 |
| creator | Jones, D. W. Mackie, I. J. Gallimore, M. J. Winter, M. |
| description | Forty female patients with either primary anti‐phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti‐phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2‐glycoprotein I and factor XII. Twenty‐one patients had a history of recurrent fetal loss (> 2, mean = 2·6). Lupus anticoagulant positivity showed a weak association with recurrent fetal loss (odds ratio = 1·1). While there was no association between the presence of antibodies to cardiolipin or beta 2‐glycoprotein I with recurrent fetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio = 5·4, P = 0·025). |
| doi_str_mv | 10.1046/j.1365-2141.2001.02776.x |
| format | article |
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W. ; Mackie, I. J. ; Gallimore, M. J. ; Winter, M.</creator><creatorcontrib>Jones, D. W. ; Mackie, I. J. ; Gallimore, M. J. ; Winter, M.</creatorcontrib><description>Forty female patients with either primary anti‐phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti‐phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2‐glycoprotein I and factor XII. Twenty‐one patients had a history of recurrent fetal loss (> 2, mean = 2·6). Lupus anticoagulant positivity showed a weak association with recurrent fetal loss (odds ratio = 1·1). While there was no association between the presence of antibodies to cardiolipin or beta 2‐glycoprotein I with recurrent fetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio = 5·4, P = 0·025).</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.2001.02776.x</identifier><identifier>PMID: 11380430</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Abortion, Habitual - complications ; Abortion, Habitual - immunology ; antibodies to factor XII ; Antibodies, Anticardiolipin - analysis ; Antiphospholipid Syndrome - complications ; Antiphospholipid Syndrome - immunology ; anti‐phospholipid syndrome ; Arterial Occlusive Diseases - immunology ; Autoantibodies - blood ; beta 2-Glycoprotein I ; Biological and medical sciences ; Confidence Intervals ; Diseases of mother, fetus and pregnancy ; factor XII ; Factor XII - immunology ; Female ; General aspects ; Glycoproteins - immunology ; Gynecology. Andrology. Obstetrics ; Humans ; Immunoglobulin G - analysis ; Immunoglobulin M - analysis ; Immunopathology ; Lupus Coagulation Inhibitor - blood ; Lupus Erythematosus, Systemic - immunology ; Medical sciences ; Odds Ratio ; Pregnancy ; Pregnancy. Fetus. Placenta ; recurrent fetal loss ; Thrombosis - immunology ; Venous Thrombosis - immunology</subject><ispartof>British journal of haematology, 2001-05, Vol.113 (2), p.550-552</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4446-4466543a1a053f8288bfaf17f6336ab73092813cae53146c95e3507c143dad923</citedby><cites>FETCH-LOGICAL-c4446-4466543a1a053f8288bfaf17f6336ab73092813cae53146c95e3507c143dad923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1046801$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11380430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, D. W.</creatorcontrib><creatorcontrib>Mackie, I. J.</creatorcontrib><creatorcontrib>Gallimore, M. J.</creatorcontrib><creatorcontrib>Winter, M.</creatorcontrib><title>Antibodies to factor XII and recurrent fetal loss in patients with the anti‐phospholipid syndrome</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Forty female patients with either primary anti‐phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti‐phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2‐glycoprotein I and factor XII. Twenty‐one patients had a history of recurrent fetal loss (> 2, mean = 2·6). Lupus anticoagulant positivity showed a weak association with recurrent fetal loss (odds ratio = 1·1). While there was no association between the presence of antibodies to cardiolipin or beta 2‐glycoprotein I with recurrent fetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio = 5·4, P = 0·025).</description><subject>Abortion, Habitual - complications</subject><subject>Abortion, Habitual - immunology</subject><subject>antibodies to factor XII</subject><subject>Antibodies, Anticardiolipin - analysis</subject><subject>Antiphospholipid Syndrome - complications</subject><subject>Antiphospholipid Syndrome - immunology</subject><subject>anti‐phospholipid syndrome</subject><subject>Arterial Occlusive Diseases - immunology</subject><subject>Autoantibodies - blood</subject><subject>beta 2-Glycoprotein I</subject><subject>Biological and medical sciences</subject><subject>Confidence Intervals</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>factor XII</subject><subject>Factor XII - immunology</subject><subject>Female</subject><subject>General aspects</subject><subject>Glycoproteins - immunology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin M - analysis</subject><subject>Immunopathology</subject><subject>Lupus Coagulation Inhibitor - blood</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Medical sciences</subject><subject>Odds Ratio</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>recurrent fetal loss</subject><subject>Thrombosis - immunology</subject><subject>Venous Thrombosis - immunology</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqNkMFu2yAYx9G0qsnSvsLEYdrN3ofBmBx26KKtSRWpl1bqDREMCpFje0CU5NZH2DP2SYqXaOuxSJ9A8PvzwQ8hTCAnwPi3TU4oL7OCMJIXACSHoqp4fviAxv8OPqIxAFRZCogR-hTCJoEUSnKJRoRQAYzCGOmbNrpVVzsTcOywVTp2Hj8tFli1NfZG77w3bcTWRNXgpgsBuxb3Krq0G_DexTWOa5Po6F6e__TrLqRqXO9qHI5t7butuUIXVjXBXJ_nCXr89fNhNs-W97eL2c0y04wxnqXiJaOKKCipFYUQK6ssqSynlKtVRWFaCEK1MiUljOtpaWgJlSaM1qqeFnSCvp7u7X33e2dClFsXtGka1ZpuF2QFIo0pSaA4gdqnD3ljZe_dVvmjJCAHwXIjB49y8CgHwfKvYHlI0c_nHrvV1tT_g2ejCfhyBlTQqrFetdqFNw0YFzA84fsJ27vGHN_dX_64mw8r-gr2ypbF</recordid><startdate>200105</startdate><enddate>200105</enddate><creator>Jones, D. W.</creator><creator>Mackie, I. J.</creator><creator>Gallimore, M. J.</creator><creator>Winter, M.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200105</creationdate><title>Antibodies to factor XII and recurrent fetal loss in patients with the anti‐phospholipid syndrome</title><author>Jones, D. W. ; Mackie, I. J. ; Gallimore, M. J. ; Winter, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4446-4466543a1a053f8288bfaf17f6336ab73092813cae53146c95e3507c143dad923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Abortion, Habitual - complications</topic><topic>Abortion, Habitual - immunology</topic><topic>antibodies to factor XII</topic><topic>Antibodies, Anticardiolipin - analysis</topic><topic>Antiphospholipid Syndrome - complications</topic><topic>Antiphospholipid Syndrome - immunology</topic><topic>anti‐phospholipid syndrome</topic><topic>Arterial Occlusive Diseases - immunology</topic><topic>Autoantibodies - blood</topic><topic>beta 2-Glycoprotein I</topic><topic>Biological and medical sciences</topic><topic>Confidence Intervals</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>factor XII</topic><topic>Factor XII - immunology</topic><topic>Female</topic><topic>General aspects</topic><topic>Glycoproteins - immunology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin M - analysis</topic><topic>Immunopathology</topic><topic>Lupus Coagulation Inhibitor - blood</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Medical sciences</topic><topic>Odds Ratio</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>recurrent fetal loss</topic><topic>Thrombosis - immunology</topic><topic>Venous Thrombosis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, D. W.</creatorcontrib><creatorcontrib>Mackie, I. J.</creatorcontrib><creatorcontrib>Gallimore, M. J.</creatorcontrib><creatorcontrib>Winter, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, D. W.</au><au>Mackie, I. J.</au><au>Gallimore, M. J.</au><au>Winter, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibodies to factor XII and recurrent fetal loss in patients with the anti‐phospholipid syndrome</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2001-05</date><risdate>2001</risdate><volume>113</volume><issue>2</issue><spage>550</spage><epage>552</epage><pages>550-552</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Forty female patients with either primary anti‐phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti‐phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2‐glycoprotein I and factor XII. Twenty‐one patients had a history of recurrent fetal loss (> 2, mean = 2·6). Lupus anticoagulant positivity showed a weak association with recurrent fetal loss (odds ratio = 1·1). While there was no association between the presence of antibodies to cardiolipin or beta 2‐glycoprotein I with recurrent fetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio = 5·4, P = 0·025).</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11380430</pmid><doi>10.1046/j.1365-2141.2001.02776.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of haematology, 2001-05, Vol.113 (2), p.550-552 |
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| language | eng |
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| source | Wiley |
| subjects | Abortion, Habitual - complications Abortion, Habitual - immunology antibodies to factor XII Antibodies, Anticardiolipin - analysis Antiphospholipid Syndrome - complications Antiphospholipid Syndrome - immunology anti‐phospholipid syndrome Arterial Occlusive Diseases - immunology Autoantibodies - blood beta 2-Glycoprotein I Biological and medical sciences Confidence Intervals Diseases of mother, fetus and pregnancy factor XII Factor XII - immunology Female General aspects Glycoproteins - immunology Gynecology. Andrology. Obstetrics Humans Immunoglobulin G - analysis Immunoglobulin M - analysis Immunopathology Lupus Coagulation Inhibitor - blood Lupus Erythematosus, Systemic - immunology Medical sciences Odds Ratio Pregnancy Pregnancy. Fetus. Placenta recurrent fetal loss Thrombosis - immunology Venous Thrombosis - immunology |
| title | Antibodies to factor XII and recurrent fetal loss in patients with the anti‐phospholipid syndrome |
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