Model Systems for Flavoenzyme Activity. Control of Flavin Recognition via Specific Electrostatic Interactions

A model system has been used to study the interactions of dipole-containing aromatic systems with oxidized and reduced flavin. Ab initio computational and experimental studies show that dipole orientation within the host is a critical determinant for recognition and redox behavior of the flavin gues...

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Bibliographic Details
Published in:Organic letters 2001-05, Vol.3 (10), p.1531-1534
Main Authors: Goodman, Allan J, Breinlinger, Eric C, McIntosh, Catherine M, Grimaldi, Lisa N, Rotello, Vincent M
Format: Article
Language:English
Subjects:
Dimerization
Flavins - metabolism
Models, Molecular
Oxidation-Reduction
Oxidoreductases - metabolism
Protein Binding
Static Electricity
Thermodynamics
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Summary:A model system has been used to study the interactions of dipole-containing aromatic systems with oxidized and reduced flavin. Ab initio computational and experimental studies show that dipole orientation within the host is a critical determinant for recognition and redox behavior of the flavin guest.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol015838l