Different prognostic impact of 24-hour mean blood pressure and pulse pressure on stroke and coronary artery disease in essential hypertension

We tested the hypothesis that the steady and pulsatile components of blood pressure (BP) exert a different influence on coronary artery disease and stroke in subjects with hypertension. We analyzed data on 2311 subjects with essential hypertension. All subjects (mean age 51 years, 47% women) underwe...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2001-05, Vol.103 (21), p.2579-2584
Main Authors: VERDECCHIA, Paolo, SCHILLACI, Giuseppe, REBOLDI, Gianpaolo, FRANKLIN, Stanley S, PORCELLATI, Carlo
Format: Article
Language:English
Subjects:
Adult
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - physiology
Blood Pressure Monitoring, Ambulatory
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Coronary Disease - etiology
Coronary Disease - physiopathology
Female
Follow-Up Studies
Humans
Hypertension - complications
Hypertension - physiopathology
Male
Medical sciences
Middle Aged
Multivariate Analysis
Prognosis
Pulse
Risk Factors
Stroke - etiology
Stroke - physiopathology
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Summary:We tested the hypothesis that the steady and pulsatile components of blood pressure (BP) exert a different influence on coronary artery disease and stroke in subjects with hypertension. We analyzed data on 2311 subjects with essential hypertension. All subjects (mean age 51 years, 47% women) underwent off-therapy 24-hour ambulatory BP monitoring. Over a follow-up period of up to 14 years (mean 4.7 years), there were 132 major cardiac events (1.20 per 100 person-years) and 105 cerebrovascular events (0.90 per 100 person-years). After adjustment for age, sex, diabetes, serum cholesterol, and cigarette smoking (all P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.103.21.2579