Hemodynamic, renal, and hormonal effects of adrenomedullin infusion in patients with congestive heart failure

Experimental studies have shown that adrenomedullin (AM) causes vasodilatation, diuresis, and a positive inotropic effect. In humans, however, whether infusion of AM has beneficial effects in congestive heart failure (CHF) remains unknown. Hemodynamic, renal, and hormonal responses to intravenous in...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2000-02, Vol.101 (5), p.498-503
Main Authors: NAGAYA, N, SATOH, T, MASUDA, Y, MIYATAKE, K, KANGAWA, K, NISHIKIMI, T, UEMATSU, M, FURUICHI, S, SAKAMAKI, F, OYA, H, KYOTANI, S, NAKANISHI, N, GOTO, Y
Format: Article
Language:English
Subjects:
Adrenomedullin
Biological and medical sciences
Cardiology. Vascular system
Cardiotonic Agents - therapeutic use
Female
Heart
Heart Failure - blood
Heart Failure - drug therapy
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hemodynamics - drug effects
Hormones - blood
Humans
Injections, Intravenous
Kidney - drug effects
Male
Medical sciences
Middle Aged
Peptides - therapeutic use
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Summary:Experimental studies have shown that adrenomedullin (AM) causes vasodilatation, diuresis, and a positive inotropic effect. In humans, however, whether infusion of AM has beneficial effects in congestive heart failure (CHF) remains unknown. Hemodynamic, renal, and hormonal responses to intravenous infusion of human AM (0.05 microg. kg(-1). min(-1)) were examined in 7 patients with CHF and 7 normal healthy subjects (NL). In NL group, AM significantly decreased mean arterial pressure (-16 mm Hg, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.101.5.498