Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons

Metabotropic glutamate receptors (mGluRs) can increase intracellular Ca2+ concentration via Ins(1,4,5)P3- and ryanodine-sensitive Ca2+ stores in neurons. Both types of store are coupled functionally to Ca2+-permeable channels found in the plasma membrane. The mGluR-mediated increase in intracellular...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2000-02, Vol.23 (2), p.80-88
Main Authors: FAGNI, L, CHAVIS, P, ANGO, F, BOCKAERT, J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcium - metabolism
Calcium Channels - metabolism
Carrier Proteins - chemistry
Carrier Proteins - genetics
Carrier Proteins - metabolism
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Homer Scaffolding Proteins
Humans
Ion Channels - metabolism
Ions
Membranes
Neuronal Plasticity
Neurons
Neurons - metabolism
Neuropeptides - chemistry
Neuropeptides - genetics
Neuropeptides - metabolism
Plasma
Potassium Channels - metabolism
Receptors, Metabotropic Glutamate - metabolism
Ryanodine Receptor Calcium Release Channel - metabolism
Vertebrates: nervous system and sense organs
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Summary:Metabotropic glutamate receptors (mGluRs) can increase intracellular Ca2+ concentration via Ins(1,4,5)P3- and ryanodine-sensitive Ca2+ stores in neurons. Both types of store are coupled functionally to Ca2+-permeable channels found in the plasma membrane. The mGluR-mediated increase in intracellular Ca2+ concentration can activate Ca2+-sensitive K+ channels and Ca2+-dependent nonselective cationic channels. These mGluR-mediated effects often result from mobilization of Ca2+ from ryanodine-sensitive, rather than Ins(1,4, 5)P3-sensitive, Ca2+ stores, suggesting that close functional interactions exist between mGluRs, intracellular Ca2+ stores and Ca2+-sensitive ion channels in the membrane.
ISSN:0166-2236
1878-108X
DOI:10.1016/s0166-2236(99)01492-7