Gene–Gene Interaction in the RAS System in the Predisposition to Myocardial Infarction in Elder Population of St. Petersburg (Russia)

The aim of this study was to estimate the frequencies of some DNA polymorphisms of two genes of the renin–angiotensin system (RAS), M235T angiotensinogen gene and insertion–deletion polymorphism in angiotensin-converting enzyme gene, in older (>55 years old) myocardial infarction survival and con...

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Bibliographic Details
Published in:Molecular genetics and metabolism 2000-01, Vol.69 (1), p.76-80
Main Authors: Fomicheva, Ekaterina V., Gukova, Svetlana P., Larionova-Vasina, Valentina I., Kovalev, Yuri R., Schwartz, Eugene I.
Format: Article
Language:English
Subjects:
ACE gene
Adolescent
Aged
Aged, 80 and over
Alleles
Amino Acid Substitution - genetics
Angiotensinogen - genetics
angiotensinogen gene
Child
Epistasis, Genetic
Gene Frequency - genetics
Genetic Predisposition to Disease - genetics
gene–gene interaction
Homozygote
Humans
Male
Middle Aged
myocardial infarction
Myocardial Infarction - genetics
Myocardial Infarction - mortality
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic - genetics
Renin-Angiotensin System - genetics
Russia
Sequence Deletion - genetics
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Summary:The aim of this study was to estimate the frequencies of some DNA polymorphisms of two genes of the renin–angiotensin system (RAS), M235T angiotensinogen gene and insertion–deletion polymorphism in angiotensin-converting enzyme gene, in older (>55 years old) myocardial infarction survival and control groups. For this purpose 198 myocardial infarction (MI) patients and 152 randomly selected healthy persons have been analyzed. We have not found any differences in allele and genotype distribution in the above-mentioned genes for either group. However, statistical research showed a significant increase of double homozygotes IITT in the group of MI patients as compared with those in the control group. In this respect we suggested that gene–gene interaction in the RAS system may be considered to be a predisposing factor for MI development.
ISSN:1096-7192
1096-7206
DOI:10.1006/mgme.1999.2924